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Automatic Human Embryo Volume Measurement in First Trimester Ultrasound From the Rotterdam Periconception Cohort: Quantitative and Qualitative Evaluation of Artificial Intelligence

Automatic Human Embryo Volume Measurement in First Trimester Ultrasound From the Rotterdam Periconception Cohort: Quantitative and Qualitative Evaluation of Artificial Intelligence

The current standard for monitoring growth and development during early pregnancy is the crown-rump length (CRL). Early measurements of the CRL are used in standard clinical practice to estimate gestational age. Moreover, CRL measurements can be used to predict miscarriages and are associated with estimated fetal weight, birth weight, and adverse pregnancy outcomes [1-5]. Volumetric measurements of the human embryo during early pregnancy are a novel way to assess growth and development.

Wietske A P Bastiaansen, Stefan Klein, Batoul Hojeij, Eleonora Rubini, Anton H J Koning, Wiro Niessen, Régine P M Steegers-Theunissen, Melek Rousian

J Med Internet Res 2025;27:e60887

Centering Birthing Experiences of Women of Color: Protocol for a Qualitative Maternal Near Miss Study

Centering Birthing Experiences of Women of Color: Protocol for a Qualitative Maternal Near Miss Study

Maternal health encompasses the well-being of both mothers and their newborns during pregnancy, childbirth, and the postpartum period. Despite advancements in medical technology and health care systems, there remain persistent challenges with maternal mortality (MM) and morbidity.

Kaitlyn Hernandez-Spalding, Oluyemi Farinu, Lasha Clarke, Tamiah Lewis, Angie Suarez, Kimarie Bugg, Kieauna Strickland, Ashley Molleti, Sherry Maxy, Natalie Hernandez-Green

JMIR Res Protoc 2025;14:e58410

Healthy Mom Zone Adaptive Intervention With a Novel Control System and Digital Platform to Manage Gestational Weight Gain in Pregnant Women With Overweight or Obesity: Study Design and Protocol for a Randomized Controlled Trial

Healthy Mom Zone Adaptive Intervention With a Novel Control System and Digital Platform to Manage Gestational Weight Gain in Pregnant Women With Overweight or Obesity: Study Design and Protocol for a Randomized Controlled Trial

High maternal prepregnancy BMI and high gestational weight gain (GWG) elevate the risks for poor pregnancy outcomes (eg, gestational diabetes and hypertension) and fetal outcomes (eg, large for gestational age birth weight) [1-6]. High BMI and GWG may also “program” the child’s metabolism for life [7,8] and increase the future risks for obesity and type 2 diabetes in both mothers and their offspring [1-6].

Danielle Symons Downs, Abigail M Pauley, Daniel E Rivera, Jennifer S Savage, Amy M Moore, Danying Shao, Sy-Miin Chow, Constantino Lagoa, Jaimey M Pauli, Owais Khan, Allen Kunselman

JMIR Res Protoc 2025;14:e66637

Evaluation of the MyFertiCoach Lifestyle App for Subfertile Couples: Single-Center Evaluation of Augmented Standard Care

Evaluation of the MyFertiCoach Lifestyle App for Subfertile Couples: Single-Center Evaluation of Augmented Standard Care

Reducing any or all of these lifestyle factors before pregnancy or assisted reproductive technology treatment can improve reproductive health [5-9]. In summary, the more negative lifestyle factors present, the lower the chance of becoming pregnant and the longer the time until pregnancy [10]. For instance, improving dietary patterns during the preconception period reduces the risk of several adverse birth outcomes, such as fetal growth restriction and babies born small or large for gestational age.

Jesper Smeenk, Ellen Smit, Marc Jacobs, Ilse van Rooij

JMIR Form Res 2025;9:e64239

Improving Maternal Mental Health and Weight Control With a Mindfulness Blended Care Approach: Insights From a Randomized Controlled Trial

Improving Maternal Mental Health and Weight Control With a Mindfulness Blended Care Approach: Insights From a Randomized Controlled Trial

In addition, each participating woman had weekly access to a self-developed digital pregnancy guide with educational and validated medical content focused on pregnancy and childbirth. The modules included for example the following topics: fears and worries about birth or parenting, coping with stress, birth-related pain control, and outlook puerperium.

Kathrin Hassdenteufel, Mitho Müller, Harald Abele, Sara Yvonne Brucker, Johanna Graf, Stephan Zipfel, Armin Bauer, Peter Jakubowski, Jan Pauluschke-Fröhlich, Markus Wallwiener, Stephanie Wallwiener

J Med Internet Res 2025;27:e56230

Evaluating the Quality, Content Accuracy, and User Suitability of mHealth Prenatal Care Apps for Expectant Mothers: Critical Assessment Study

Evaluating the Quality, Content Accuracy, and User Suitability of mHealth Prenatal Care Apps for Expectant Mothers: Critical Assessment Study

Pregnancy apps, in particular, have become popular resources for expectant mothers, offering functionalities ranging from fetal development tracking to health tips and educational content [6,7]. However, the reliability of health recommendations provided by pregnancy apps remains a significant concern.

Fateme Asadollahi, Samira Ebrahimzadeh Zagami, Saeid Eslami, Robab Latifnejad Roudsari

Asian Pac Isl Nurs J 2025;9:e66852

Usability and Acceptability of a Pregnancy App for Substance Use Screening and Education: A Mixed Methods Exploratory Pilot Study

Usability and Acceptability of a Pregnancy App for Substance Use Screening and Education: A Mixed Methods Exploratory Pilot Study

Substance use during pregnancy has increased significantly over the past two decades [1-4], with almost 3% of pregnant people having a formal substance use disorder diagnosis [5]. Opioid use disorder during pregnancy has more than quadrupled in the past 20 years and is now a leading cause of maternal death in the United States [6-12]. Observed rates of other substance use during pregnancy have also increased in recent years, including cannabis, alcohol, sedatives, and stimulants.

Haley Fitzgerald, Madison Frank, Katelyn Kasula, Elizabeth E Krans, Tamar Krishnamurti

JMIR Pediatr Parent 2025;8:e60038

Privacy Concerns Versus Personalized Health Content—Pregnant Individuals’ Willingness to Share Personal Health Information on Social Media: Survey Study

Privacy Concerns Versus Personalized Health Content—Pregnant Individuals’ Willingness to Share Personal Health Information on Social Media: Survey Study

Pregnancy is a vulnerable period that exposes patients to heightened anxiety, depression, and stress, leading to adverse maternal, infant, and family outcomes, disproportionately affecting disadvantaged families [9,10]. The negative impact can be mitigated by interventions from health care providers [11,12]. However, disparities in access to health care, health literacy, socioeconomic status, and neighborhood characteristics strangle equitable access to clinical interventions [12-14].

Haijing Hao, Yang W Lee, Marianne Sharko, Qilu Li, Yiye Zhang

JMIR Form Res 2025;9:e60862

Proficiency, Clarity, and Objectivity of Large Language Models Versus Specialists’ Knowledge on COVID-19's Impacts in Pregnancy: Cross-Sectional Pilot Study

Proficiency, Clarity, and Objectivity of Large Language Models Versus Specialists’ Knowledge on COVID-19's Impacts in Pregnancy: Cross-Sectional Pilot Study

Pregnancy, by its nature, puts women at a higher risk for complications from viral infections like COVID-19 [5,6]. As vaccines became available, gynecologists and obstetricians were at the forefront, recommending COVID-19 vaccinations to pregnant women, and having to balance the lack of initial data on vaccine safety in pregnancy with the known risks of COVID-19, providing tailored advice to their patients.

Nicola Luigi Bragazzi, Michèle Buchinger, Hisham Atwan, Ruba Tuma, Francesco Chirico, Lukasz Szarpak, Raymond Farah, Rola Khamisy-Farah

JMIR Form Res 2025;9:e56126

The Research Agenda for Perinatal Innovation and Digital Health Project: Human-Centered Approach to Multipartner Research Agenda Codevelopment

The Research Agenda for Perinatal Innovation and Digital Health Project: Human-Centered Approach to Multipartner Research Agenda Codevelopment

Based on the identified gaps, strategies, and needed tools, three potential areas for research were identified: (1) What is the best way to use telecommunication and information technologies to provide health care services during pregnancy and childbirth remotely? (2) What is the best design and implementation strategy to enable a shared electronic antenatal health record that can be accessed by any health care provider and patient during pregnancy?

Haneen Amhaz, Sally Xuanping Chen, Amanee Elchehimi, Kylin Jialin Han, Jade Morales Gil, Lu Yao, Marianne Vidler, Kathryn Berry-Einarson, Kathryn Dewar, May Tuason, Nicole Prestley, Quynh Doan, Tibor van Rooij, Tina Costa, Gina Ogilvie, Beth A Payne

JMIR Hum Factors 2025;12:e60825