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Noninvasive, Multimodal Inflammatory Biomarker Discovery for Systemic Inflammation (NOVA Study): Protocol for a Cross-Sectional Study

Noninvasive, Multimodal Inflammatory Biomarker Discovery for Systemic Inflammation (NOVA Study): Protocol for a Cross-Sectional Study

Recent studies have shown encouraging results including significant associations with serum calprotectin in patients with spondyloarthritis compared with matched controls and increased serum calprotectin levels correlated with disease activity in both rheumatoid arthritis and axial spondyloarthritis [11,12].

Jinjoo Shim, Sinziana Muraru, Rucsandra Dobrota, Elgar Fleisch, Oliver Distler, Filipe Barata

JMIR Res Protoc 2024;13:e62877

Deciphering the Role of Insulin-Like Growth Factor 1 in Endometrial Cancer in Patients With Polycystic Ovary Syndrome: Protocol for a Methodological Approach Using Cell Culture Experiments

Deciphering the Role of Insulin-Like Growth Factor 1 in Endometrial Cancer in Patients With Polycystic Ovary Syndrome: Protocol for a Methodological Approach Using Cell Culture Experiments

We will aim not to exceed 24 hours and isolate serum within 1 or 2 hours of blood collection. Once the blood has been clotted, it will be centrifuged at 1000 x gravitational units (g) for 10 minutes in a refrigerated centrifuge (at 4˚C) to facilitate the separation of the serum. A barrier will form between the serum and the cells; if no barrier is formed, the sample will be respun for 5 minutes.

William Atiomo, Fatma Alqutami, Sara Albasha, Mahmood Hachim

JMIR Res Protoc 2023;12:e48127

Cognitive Dysfunction and Affective Mood Disorder Screening in Patients With Chronic Inflammatory Bowel Disease: Protocol for a Prospective Case-Control Study

Cognitive Dysfunction and Affective Mood Disorder Screening in Patients With Chronic Inflammatory Bowel Disease: Protocol for a Prospective Case-Control Study

We will obtain the serum from 5 m L of the blood sample of each participant and quantitatively measure serum SAA, Hcy, S100 B, BDNF levels. The blood samples will be obtained at baseline. Other blood measurements will be performed at the hospital’s laboratory as part of the visit, and values will be taken from the registry. All the necessary data that will be obtained from blood testing are mentioned in Table 14.

Oliviu Florentiu Sarb, Vitalie Vacaras, Adriana Sarb, Maria Iacobescu, Alina-Ioana Tantau

JMIR Res Protoc 2023;12:e50546

The Association Between Borderline Dysnatremia and Perioperative Morbidity and Mortality: Retrospective Cohort Study of the American College of Surgeons National Surgical Quality Improvement Program Database

The Association Between Borderline Dysnatremia and Perioperative Morbidity and Mortality: Retrospective Cohort Study of the American College of Surgeons National Surgical Quality Improvement Program Database

Many previous studies investigating patient outcomes categorize sodium levels as hyponatremic (serum sodium concentration less than 135 m Eq/L), eunatremic, and hypernatremic (serum sodium concentration greater than 145 m Eq/L) [1,9-11]. Some studies also identified an increased risk of in-hospital and 1-year mortality in hospitalized patients with mild hyponatremia (125-134 m Eq/L) and hypernatremia (146-150 m Eq/L) [12,13].

Jacob H Cole, Krista B Highland, Scott B Hughey, Brendan J O'Shea, Thomas Hauert, Ashton H Goldman, George C Balazs, Gregory J Booth

JMIR Perioper Med 2023;6:e38462

Correlation Between Serum and Urine Biomarkers and the Intensity of Acute Radiation Cystitis in Patients Treated With Radiation Therapy for Localized Prostate Cancer: Protocol for the Radiotoxicity Bladder Biomarkers (RABBIO) Study

Correlation Between Serum and Urine Biomarkers and the Intensity of Acute Radiation Cystitis in Patients Treated With Radiation Therapy for Localized Prostate Cancer: Protocol for the Radiotoxicity Bladder Biomarkers (RABBIO) Study

Based on the biomarkers reported in the literature, we chose to assess variations in the expression of 33 serum and urine biomarkers [9,28]. Biomarkers of urinary and intestinal microbiota may be prognostic of radiation-induced functional disorders [18-20]. Thus, we chose to assess changes in the composition of the urinary and fecal microbiota before, during, and after radiotherapy.

Carole Helissey, Sophie Cavallero, Stanislas Mondot, Charles Parnot, Halima Yssaad, Selma Becherirat, Nathalie Guitard, Hélène Thery, Antoine Schernberg, Hugo Breitwiller, Cyrus Chargari, Sabine Francois

JMIR Res Protoc 2023;12:e38362