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To address this research gap, we propose a proof-of-concept feasibility study (NOVA study) to evaluate the relationship between the levels of serum inflammatory biomarkers and those measured noninvasively in urine, sweat, saliva, exhaled breath, core body temperature, and stool in patients with systemic inflammation.
JMIR Res Protoc 2024;13:e62877
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Part III of the study builds up a liquid biobank from biosamples (blood, urine, stool, saliva) of study part II participants, with samples taken prior to endoscopy. The main objective of study part III is the evaluation of less invasive methods of CRC screening and further characterization of detected neoplasms and defining biomarkers or biomarker panels of different composition (such as proteins, metabolites, DNA, micro RNA, methylation markers) obtained via different -omics platforms.
DARIO study design.
JMIR Res Protoc 2020;9(8):e17516
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