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Noninvasive, Multimodal Inflammatory Biomarker Discovery for Systemic Inflammation (NOVA Study): Protocol for a Cross-Sectional Study

Noninvasive, Multimodal Inflammatory Biomarker Discovery for Systemic Inflammation (NOVA Study): Protocol for a Cross-Sectional Study

To address this research gap, we propose a proof-of-concept feasibility study (NOVA study) to evaluate the relationship between the levels of serum inflammatory biomarkers and those measured noninvasively in urine, sweat, saliva, exhaled breath, core body temperature, and stool in patients with systemic inflammation.

Jinjoo Shim, Sinziana Muraru, Rucsandra Dobrota, Elgar Fleisch, Oliver Distler, Filipe Barata

JMIR Res Protoc 2024;13:e62877

Effects of Alternative Offers of Screening Sigmoidoscopy and Colonoscopy on Utilization and Yield of Endoscopic Screening for Colorectal Neoplasms: Protocol of the DARIO Randomized Trial

Effects of Alternative Offers of Screening Sigmoidoscopy and Colonoscopy on Utilization and Yield of Endoscopic Screening for Colorectal Neoplasms: Protocol of the DARIO Randomized Trial

Part III of the study builds up a liquid biobank from biosamples (blood, urine, stool, saliva) of study part II participants, with samples taken prior to endoscopy. The main objective of study part III is the evaluation of less invasive methods of CRC screening and further characterization of detected neoplasms and defining biomarkers or biomarker panels of different composition (such as proteins, metabolites, DNA, micro RNA, methylation markers) obtained via different -omics platforms. DARIO study design.

Petra Schrotz-King, Michael Hoffmeister, Peter Sauer, Anja Schaible, Hermann Brenner

JMIR Res Protoc 2020;9(8):e17516