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The Endocrine Society guidelines recommend a testosterone therapy regimen consisting of intramuscular or subcutaneous testosterone at an initial dose of 25 mg/m2 every 2 weeks with a gradual increase in the dose every 6 months until an adult dose of 100-200 mg every 2 weeks is achieved [3].
JMIR Res Protoc 2024;13:e57931
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Phoenix et al [3], in their seminal paper, reported that female rat pups that were exposed to testosterone during pregnancy displayed male sexual behavior in adulthood. Later, Feder and Whalen [4] found that male pups that were castrated shortly after birth (but still within the sensitive period) showed feminine sexual behavior as adults.
The exposure to androgens (eg, testosterone) before birth also influences the digit ratio (DR) or the ratio of finger lengths of the second and fourth digits (2 D:4 D) [5].
JMIR Res Protoc 2021;10(10):e29199
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Testosterone supplementation has been shown to prevent impaired bone and muscle mass, and improved body composition, quality of life, and physical ability in a controlled study of the effect of testosterone without concurrent training for elderly men with low and slightly reduced testosterone levels [25]. Additional studies are needed to verify the above-mentioned results.
JMIR Res Protoc 2018;7(3):e71
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