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Skip search results from other journals and go to results- 12 JMIR Research Protocols
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Meanwhile, by showing that perfectionism is negatively related to the PUI symptom cluster, our findings extend previous assumptions on the potential protective role of perfectionism (underpinned by conscientiousness) in problematic alcohol use [44] to suggest that such a protective effect may be transdiagnostic across substance use and behavioral addictions.
Current findings addressed several key research priorities identified by experts [1,2].
J Med Internet Res 2025;27:e66191
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A burgeoning literature suggests that cognitive remediation may be a promising transdiagnostic intervention approach [28,47-55]. Working memory training has been found to reduce the recurrence of mood episodes among patients with remitted MDD, with stronger protective effects—apparent up to 2 years after the intervention—for those who reported reduced rumination after training [52,56].
JMIR Res Protoc 2025;14:e54221
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This study evaluates a peer-supported, transdiagnostic m Health program for trauma-exposed veterans. Given the frequency of comorbid symptomatology among trauma-exposed populations [1,28], a transdiagnostic approach, if successful, provides the opportunity for broad use across various trauma-exposed populations with diverse needs. Moreover, different types of symptoms share issues with emotion regulation and psychosocial functioning, making these difficulties important treatment targets.
J Med Internet Res 2024;26:e52130
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Due to high rates of comorbidity between mental disorders in university student populations [35], transdiagnostic approaches that deliver therapeutic content targeting the common mechanisms that underlie mental disorders may have more clinical utility than disorder-specific approaches.
J Med Internet Res 2024;26:e53598
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Transdiagnostic web-based approaches may broaden the scope and impact of interventions. This is particularly relevant given the high comorbidity of symptoms among students [5]. There is a growing consensus that depression and anxiety, although often classified as distinct disorders, share common etiological and perpetuating factors, such as proneness to internalization and high levels of negative affect [22,23].
JMIR Ment Health 2024;11:e50503
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This was the first online transdiagnostic prevention program targeting the LGB group based on the ACT framework. Despite previous calls to use standard ACT [40] or affirmative ACT [41] for LGBTQ+ communities, this is the first ACT-inspired open trial tailored for LGBTQ+ people. It is not, however, the first mental health program tailored to the LGBTQ+ community. For example, Pachankis et al [26] used a 10-session LGBTQ+ tailored CBT.
JMIR Form Res 2024;8:e56198
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Notably, CBT treatment protocols for anxiety disorders with proven effectiveness span from disorder-specific to transdiagnostic treatment protocols (eg, Dalgleish et al [5]). Despite their evidence base and recommendations by current treatment guidelines (eg, National Institute for Heath and Care Excellence treatment guidelines), there remains significant room for improvement. Only about half of the individuals treated with CBT experience full remission or clinically meaningful symptom reduction [6,7].
JMIR Res Protoc 2024;13:e42547
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The intervention incorporates a transdiagnostic approach to MH (ie, Unified Protocol for Transdiagnostic Treatment of Emotional Disorders [35]) and implements techniques from various therapeutic approaches, such as positive psychology [36], mindfulness [37], acceptance and commitment therapy (ACT) [38], self-compassion [39], and cognitive behavioral therapy [40], to accommodate the diverse needs and content preferences of the student population.
JMIR Res Protoc 2023;12:e46603
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This finding may explain the transdiagnostic effects of many pharmaceutical and psychosocial treatments for a range of mental disorders [8,9]. As a result, mental health treatment approaches are shifting toward transdiagnostic interventions which are based on common underlying mechanisms of mental illness that have been proven to be effective across diagnoses [10].
JMIR Res Protoc 2023;12:e46651
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Initially, the PSPNET team adapted an existing transdiagnostic ICBT course that had demonstrated effectiveness in the general population in Australia and the Canadian province of Saskatchewan [30-33]. This course was tailored for Canadian PSP and was titled the PSP Wellbeing Course. Initial research results from the PSP Wellbeing Course showed that tailored ICBT was used by PSP to address both occupational and personal concerns [34] and was viewed as beneficial [35].
JMIR Form Res 2023;7:e51088
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