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Peer Review of “Identifying Safeguards Disabled by Epstein-Barr Virus Infections in Genomes From Patients With Breast Cancer: Chromosomal Bioinformatics Analysis”

Peer Review of “Identifying Safeguards Disabled by Epstein-Barr Virus Infections in Genomes From Patients With Breast Cancer: Chromosomal Bioinformatics Analysis”

The interpretation of viral homology and its impact on cancer development is speculative in several sections. The connections made between EBV infections, chromosomal breakpoints, and cancerous mutations rely heavily on correlative data without sufficient causal evidence. A more cautious interpretation of the results, highlighting the need for further experimental validation, would strengthen the manuscript.

Anonymous

JMIRx Med 2025;6:e70041

Author’s Response to Peer Reviews of “Identifying Safeguards Disabled by Epstein-Barr Virus Infections in Genomes From Patients With Breast Cancer: Chromosomal Bioinformatics Analysis”

Author’s Response to Peer Reviews of “Identifying Safeguards Disabled by Epstein-Barr Virus Infections in Genomes From Patients With Breast Cancer: Chromosomal Bioinformatics Analysis”

The interpretation of viral homology and its impact on cancer development is speculative in several sections. The connections made between EBV infections, chromosomal breakpoints, and cancerous mutations rely heavily on correlative data without sufficient causal evidence. A more cautious interpretation of the results, highlighting the need for further experimental validation, would strengthen the manuscript.

Bernard Friedenson

JMIRx Med 2025;6:e69307

Identifying Safeguards Disabled by Epstein-Barr Virus Infections in Genomes From Patients With Breast Cancer: Chromosomal Bioinformatics Analysis

Identifying Safeguards Disabled by Epstein-Barr Virus Infections in Genomes From Patients With Breast Cancer: Chromosomal Bioinformatics Analysis

A graph of viral sequences in humans against chromothripsis breaks in breast cancers was so complex that it resisted interpretation, so only the 5 viral sequences nearest the chromothripsis breaks were used. The viral sequences nearest high-confidence chromothripsis breaks were determined in 5 iterations as genome coordinates where XLOOKUP values gave the minimum distances. Distances between all virus homology start points were then compared to all chromothripsis breakpoints.

Bernard Friedenson

JMIRx Med 2025;6:e50712

Assessing SARS-CoV-2 Testing Adherence in a University Town: Recurrent Event Modeling Analysis

Assessing SARS-CoV-2 Testing Adherence in a University Town: Recurrent Event Modeling Analysis

Early detection of cases can limit viral transmission by isolation, quarantine, and contact tracing [10-12]. New preventive and surveillance mechanisms surged throughout the pandemic, including vaccine programs, wastewater surveillance [13], and at-home COVID-19 tests [14]. Both the virus itself and protective behaviors changed throughout the waves of the pandemic [1], complicating long-term interventions.

Yury E García, Alec J Schmidt, Leslie Solis, María L Daza-Torres, J Cricelio Montesinos-López, Brad H Pollock, Miriam Nuño

JMIR Public Health Surveill 2024;10:e48784

Delivery of the HIV Service and Telemedicine Through Effective Patient-Reported Outcomes (+STEP) Intervention to Increase Screening and Treatment of Mental Health and Substance Use Disorders for People Living With HIV in Alabama: Protocol for an Effectiveness-Implementation Study

Delivery of the HIV Service and Telemedicine Through Effective Patient-Reported Outcomes (+STEP) Intervention to Increase Screening and Treatment of Mental Health and Substance Use Disorders for People Living With HIV in Alabama: Protocol for an Effectiveness-Implementation Study

This syndemic jeopardizes HIV treatment adherence, engagement in care, and viral load (VL) suppression [6]. Specifically, MH and SUD are associated with reduced antiretroviral treatment (ART) adherence, high viral load levels, and increased mortality [7,8]. persons living with HIV with MH and SUD may be reluctant to report these conditions due to stigma, medical mistrust, or social desirability bias, but diagnosis is an essential first step toward management of these comorbidities [6,9].

Kelly W Gagnon, Stefan Baral, Dustin Long, Alfredo L Guzman, Bernadette Johnson, Greer Burkholder, James Willig, Michael Mugavero, Margaret Baldwin, Susanne Fogger, Thomas Creger, Karen Cropsey, Ellen Eaton

JMIR Res Protoc 2023;12:e40470

Evaluation of Mpox Knowledge, Stigma, and Willingness to Vaccinate for Mpox: Cross-Sectional Web-Based Survey Among Sexual and Gender Minorities

Evaluation of Mpox Knowledge, Stigma, and Willingness to Vaccinate for Mpox: Cross-Sectional Web-Based Survey Among Sexual and Gender Minorities

People living with HIV answered questions about the time since the diagnosis (≤6, >6-12, and >12 months), about antiretroviral therapy (ART) use, ART adherence using a validated scale [23], and if they currently had an undetectable HIV viral load (yes or no). Participants self-reporting negative or unknown status were asked about HIV pre-exposure prophylaxis (Pr EP) use (never, current, or past) and adherence (rated from 0 [missed all doses in past 30 days] to 100 [no missing dose]).

Thiago Silva Torres, Mayara Secco Torres Silva, Carolina Coutinho, Brenda Hoagland, Emilia Moreira Jalil, Sandra Wagner Cardoso, Julio Moreira, Monica Avelar Magalhaes, Paula Mendes Luz, Valdilea G Veloso, Beatriz Grinsztejn

JMIR Public Health Surveill 2023;9:e46489

Factors Driving the Popularity and Virality of COVID-19 Vaccine Discourse on Twitter: Text Mining and Data Visualization Study

Factors Driving the Popularity and Virality of COVID-19 Vaccine Discourse on Twitter: Text Mining and Data Visualization Study

Johnson & Johnson’s Janssen vaccine, which is based on a slightly more mature technology of a viral vector, became the third vaccine approved for emergency use in the United States in February 2020 [6]. Owing to their novelty, COVID-19 vaccines had potential to fuel the existing vaccine debate, including arguments over vaccine safety and effectiveness, which had received notable attention in recent years before the pandemic [7].

Jueman Zhang, Yi Wang, Molu Shi, Xiuli Wang

JMIR Public Health Surveill 2021;7(12):e32814