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Epidemiological Characteristics of Intestinal Protozoal Infections and Their Risk Factors in Malaysia: Systematic Review and Meta-Analysis Protocol

Epidemiological Characteristics of Intestinal Protozoal Infections and Their Risk Factors in Malaysia: Systematic Review and Meta-Analysis Protocol

The most common symptoms of an intestinal protozoal infection include nausea and watery diarrhea, which are caused by the release of enterotoxins, and are often accompanied by inflammation in the stomach, small intestine, and large intestine [3]. Individuals infected with E. histolytica, the causative agent of amoebiasis, show characteristic symptoms such as abdominal pain, bloody diarrhea, fever, and in severe cases, liver abscesses.

Nor Shazlina Mizan, Hassanain Al-Talib, Seok Mui Wang

JMIR Res Protoc 2025;14:e66350

The Impact of Rapid Handpump Repairs on Diarrhea Morbidity in Children: Cross-Sectional Study in Kwale County, Kenya

The Impact of Rapid Handpump Repairs on Diarrhea Morbidity in Children: Cross-Sectional Study in Kwale County, Kenya

The first technique compared child diarrhea prevalence (during a 2-week period) in the same households before and after the repair service was introduced to control for time-invariant household characteristics. The second approach involved a cross-sectional analysis comparing households reporting diarrhea with those not reporting diarrhea, adjusting for household characteristics gathered at the same time as the self-reported diarrhea data.

Patrick Thomson, Justin Stoler, Michelle Byford, David J Bradley

JMIR Public Health Surveill 2024;10:e42462

Association of Search Query Interest in Gastrointestinal Symptoms With COVID-19 Diagnosis in the United States: Infodemiology Study

Association of Search Query Interest in Gastrointestinal Symptoms With COVID-19 Diagnosis in the United States: Infodemiology Study

Notably, the diarrhea search query share also increases at the same time or slightly after those for fever and cough. The search query shares for the remaining gastrointestinal symptoms are either only very slightly above baseline (nausea and vomiting) or below baseline (abdominal pain and constipation). The search query shares for fever, cough, and diarrhea all appear to decline after March 20 despite a continued steady rise in cumulative cases through June 15.

Anjana Rajan, Ravi Sharaf, Robert S Brown, Reem Z Sharaiha, Benjamin Lebwohl, SriHari Mahadev

JMIR Public Health Surveill 2020;6(3):e19354

A Fully Integrated Real-Time Detection, Diagnosis, and Control of Community Diarrheal Disease Clusters and Outbreaks (the INTEGRATE Project): Protocol for an Enhanced Surveillance System

A Fully Integrated Real-Time Detection, Diagnosis, and Control of Community Diarrheal Disease Clusters and Outbreaks (the INTEGRATE Project): Protocol for an Enhanced Surveillance System

Traditional surveillance methods tend to detect point-source outbreaks of diarrhea and vomiting; however, they are less effective at identifying low-level and intermittent contamination of the food supply, unless the organism is very rare. Furthermore, it may take up to 9 weeks for infections to be confirmed by a reference laboratory, reducing recognition of slow-burn outbreaks that can affect hundreds or thousands of people over a wide geographical area.

Kirsty Marie McIntyre, Frederick J Bolton, Rob M Christley, Paul Cleary, Elizabeth Deja, Ann E Durie, Peter J Diggle, Dyfrig A Hughes, Simon de Lusignan, Lois Orton, Alan D Radford, Alex J Elliot, Gillian E Smith, Darlene A Snape, Debbi Stanistreet, Roberto Vivancos, Craig Winstanley, Sarah J O’Brien

JMIR Res Protoc 2019;8(9):e13941

An Integrated Approach to Control Soil-Transmitted Helminthiasis, Schistosomiasis, Intestinal Protozoa Infection, and Diarrhea: Protocol for a Cluster Randomized Trial

An Integrated Approach to Control Soil-Transmitted Helminthiasis, Schistosomiasis, Intestinal Protozoa Infection, and Diarrhea: Protocol for a Cluster Randomized Trial

There is evidence that a considerable part of the global burden of disease is attributable to unsafe sanitation, poor water quality, and inadequate hygiene behavior [13,14] and that improved sanitation and water supply are key factors for prevention, control, and elimination of helminthiases and diarrhea [11,15-18]. Yet, current control efforts do not take these aspects sufficiently into account.

Giovanna Raso, Clémence Essé, Kouassi Dongo, Mamadou Ouattara, Fabien Zouzou, Eveline Hürlimann, Veronique A Koffi, Gaoussou Coulibaly, Virginie Mahan, Richard B Yapi, Siaka Koné, Jean Tenena Coulibaly, Aboulaye Meïté, Marie-Claire Guéhi-Kabran, Bassirou Bonfoh, Eliézer Kouakou N'Goran, Jürg Utzinger

JMIR Res Protoc 2018;7(6):e145

Performance of a Mobile Phone App-Based Participatory Syndromic Surveillance System for Acute Febrile Illness and Acute Gastroenteritis in Rural Guatemala

Performance of a Mobile Phone App-Based Participatory Syndromic Surveillance System for Acute Febrile Illness and Acute Gastroenteritis in Rural Guatemala

Similar to most LMICs, Guatemala has limited experience with participatory syndromic surveillance and relies almost entirely on passive, centralized surveillance systems to estimate disease burden, including for important emerging pathogens such as dengue virus and norovirus, two of the most common causes of fever and diarrhea, respectively [16-19].

Daniel Olson, Molly Lamb, Maria Renee Lopez, Kathryn Colborn, Alejandra Paniagua-Avila, Alma Zacarias, Ricardo Zambrano-Perilla, Sergio Ricardo Rodríguez-Castro, Celia Cordon-Rosales, Edwin Jose Asturias

J Med Internet Res 2017;19(11):e368

Efficacy of Lactobacillus Reuteri DSM 17938 for the Treatment of Acute Gastroenteritis in Children: Protocol of a Randomized Controlled Trial

Efficacy of Lactobacillus Reuteri DSM 17938 for the Treatment of Acute Gastroenteritis in Children: Protocol of a Randomized Controlled Trial

A 2012 study by Francavilla et al [13] was carried out in 74 children with acute diarrhea randomized to receive L reuteri DSM 17938 (at a dose of 4×108colony-forming units [CFU]) or placebo for 7 days.

Henryk Szymański, Hania Szajewska

JMIR Res Protoc 2017;6(8):e164

Pretravel Health Advice Among Australians Returning From Bali, Indonesia: A Randomized Controlled Trial Protocol

Pretravel Health Advice Among Australians Returning From Bali, Indonesia: A Randomized Controlled Trial Protocol

In particular, while notifiable disease data are available, there are no comparable data available for non-notifiable illnesses, such as traveler’s diarrhea, among residents returning to Western Australia. Delivering appropriate and effective pretravel health advice (PTHA) to travelers may be important to reduce the risk of illness to travelers and to prevent the importation of travel-related diseases [5].

Chloe A. Alexandra Thomson, Robyn A Gibbs, Jane S Heyworth, Carolien Giele, Martin J Firth, Paul V Effler

JMIR Res Protoc 2016;5(4):e236

A Multicenter Prospective Study to Investigate the Diagnostic Accuracy of the SeHCAT Test in Measuring Bile Acid Malabsorption: Research Protocol

A Multicenter Prospective Study to Investigate the Diagnostic Accuracy of the SeHCAT Test in Measuring Bile Acid Malabsorption: Research Protocol

Chronic diarrhea is a common problem and the investigation and management of the condition places a significant burden on health services as well as on affected patients. The suggestion that bile acid malabsorption (BAM) can cause diarrhea was first described by Hofmann in 1967 [1]; since then, BAM has been identified as a possible explanation for persistent chronic diarrhea. Bile acids are produced in the liver, stored in the gallbladder, and released upon eating for the digestion of dietary fat.

Fiona Reid, Janet Peacock, Bola Coker, Viktoria McMillan, Cornelius Lewis, Stephen Keevil, Roy Sherwood, Gill Vivian, Robert Logan, Jennifer Summers

JMIR Res Protoc 2016;5(1):e13