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Dear Author,
After a thorough review of the paper titled “Herpesvirus infections eliminate safeguards against breast cancer and its metastasis: comparable to hereditary breast cancers” [1] by Bernard Friedenson, here is the negative feedback and evaluation, along with a recommendation for the inclusion of a specific article in the discussion section.
The paper ambitiously attempts to link Epstein-Barr virus (EBV) infections to breast cancer development and metastasis.
JMIRx Med 2025;6:e70041
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Title: “Herpesvirus infections eliminate safeguards against breast cancer and its metastasis: comparable to hereditary breast cancers”
The paper [1] hypothesizes that Epstein-Barr virus (EBV) infections promote breast cancer by disabling cancer safeguards. It is a bioinformatics analysis of public information from about 2100 breast cancers.
JMIRx Med 2025;6:e70039
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Title: “Herpesvirus infections eliminate safeguards against breast cancer and its metastasis: comparable to hereditary breast cancers”
The paper [2] hypothesizes that Epstein-Barr virus (EBV) infections promote breast cancer by disabling cancer safeguards. It is a bioinformatics analysis of public information from about 2100 breast cancers.
JMIRx Med 2025;6:e69307
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These coordinates were unlikely to be completely random since they did not follow a normal distribution (P
The last question was whether EBV contributes to breast cancer metastasis. According to Yates et al [29], relapsed and metastatic breast cancer tumors keep their tumor-driver gene mutations and continue acquiring new ones. Late mutations in JAK-STAT and SWI-SNF signaling pathways drive established breast cancers into metastasis.
JMIRx Med 2025;6:e50712
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Merkel Cell Carcinoma on the Face: Case Report
MCC is a cutaneous neuroendocrine carcinoma that is aggressive and has a high tendency for metastasis. Because of the lack of symptoms, it is difficult to make an early diagnosis of MCC, which is often misinterpreted as a subcutaneous benign tumor, squamous cell carcinoma, or melanoma [5]. Some uncommon skin lesions, including MCC, require a high index of suspicion to be diagnosed. It is an uncommon and aggressive neuroendocrine skin tumor that accounts for fewer than 1% of all cutaneous malignancies.
JMIR Dermatol 2024;7:e56658
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Axillary dissection vs no axillary dissection in women with invasive breast cancer and sentinel node metastasismetastasis
JMIR Perioper Med 2022;5(1):e34600
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Hepatic Metastasis Revealing a Melanoma of the Penis: Case Report
Others use the American Joint Committee on Cancer (AJCC) tumor-node-metastasis (TNM) cancer staging system [15]. The patient presented in this case report was assessed as having AJCC stage III (T4 N2 M1) melanoma of the penis.
Imaging does not usually play an important role in the diagnosis but rather in the assessment of extension, particularly in the search for distant lesions, and in the follow-up.
JMIR Dermatol 2022;5(3):e37400
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