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Large-Scale Evaluation and Liver Disease Risk Prediction in Finland’s National Electronic Health Record System: Feasibility Study Using Real-World Data

Large-Scale Evaluation and Liver Disease Risk Prediction in Finland’s National Electronic Health Record System: Feasibility Study Using Real-World Data

In this case, the mortality rate is very high. Although similar research has not been conducted in Finland, the situation is presumed to be equally concerning. There are automated methodologies implemented to diagnose liver fibrosis, but large-scale systematic analysis and screening are still yet to be implemented because of missing nationwide data. One randomized controlled study developed a care pathway for identifying advanced liver disease in patients with type 2 diabetes in Hong Kong and Malaysia.

Viljami Männikkö, Janne Tommola, Emmi Tikkanen, Olli-Pekka Hätinen, Fredrik Åberg

JMIR Med Inform 2025;13:e62978

Effect of a Telemedicine Model on Patients With Heart Failure With Reduced Ejection Fraction in a Resource-Limited Setting in Vietnam: Cohort Study

Effect of a Telemedicine Model on Patients With Heart Failure With Reduced Ejection Fraction in a Resource-Limited Setting in Vietnam: Cohort Study

Despite significant advances in HF treatment over the past decades, mortality rates remain high, with 1-year mortality rates ranging from 14% to 30% and 5-year rates ranging from 50% to 75% [3,5]. Additionally, patients with HF frequently require hospitalization due to acute exacerbations of the disease, making HF the leading cause of hospitalization for individuals older than 65 years in Europe [2,5-7].

Hoai Thi Thu Nguyen, Hieu Ba Tran, Phuong Minh Tran, Hung Manh Pham, Co Xuan Dao, Thanh Ngoc Le, Loi Doan Do, Ha Quoc Nguyen, Thom Thi Vu, James Kirkpatrick, Christopher Reid, Dung Viet Nguyen

J Med Internet Res 2025;27:e67228

Comparative Evaluation of Effectiveness of Standard of Care Alone and in Combination With Homoeopathic Treatment in COVID-19–Related Rhino-Orbito-Cerebral Mucormycosis (ROCM): Protocol for a Single Blind, Randomized Controlled Trial

Comparative Evaluation of Effectiveness of Standard of Care Alone and in Combination With Homoeopathic Treatment in COVID-19–Related Rhino-Orbito-Cerebral Mucormycosis (ROCM): Protocol for a Single Blind, Randomized Controlled Trial

Despite all efforts in the conventional line of treatment, ROCM has a mortality rate of 40%-50% and 70% of survivors are left with residual defects [18]. To reduce the high mortality rate and residual defect in most of the survivors, Ministry of AYUSH, Government of India [19] has recommended homoeopathy as an add-on therapy to maximize the effectiveness of the standard line of treatment in conventional therapy.

Harleen Kaur, Jyoti Sachdeva, Ramesh Bawaskar, Twinkle Goyal

JMIR Res Protoc 2025;14:e57905

Targeted Behavior Change Communication Using a Mobile Health Platform to Increase Uptake of Long-Lasting Insecticidal Nets Among Pregnant Women in Tanzania: Hati Salama “Secure Voucher” Study Cluster Randomized Controlled Trial

Targeted Behavior Change Communication Using a Mobile Health Platform to Increase Uptake of Long-Lasting Insecticidal Nets Among Pregnant Women in Tanzania: Hati Salama “Secure Voucher” Study Cluster Randomized Controlled Trial

Pregnant women and adolescents are at heightened risk of morbidity and mortality by malaria, with 22% of pregnant women exposed to malaria in East and Southern Africa in 2020 [1]. Malaria infection during pregnancy can result in miscarriage, premature delivery, low birth weight, or death in neonates, as well as maternal anemia and maternal death [2].

Trinity Vey, Eleonora Kinnicutt, Andrew G Day, Nicola West, Jessica Sleeth, Kenneth Bernard Nchimbi, Karen Yeates

J Med Internet Res 2025;27:e51524

Digital Health Literacy and Attitudes Toward eHealth Technologies Among Patients With Cardiovascular Disease and Their Implications for Secondary Prevention: Survey Study

Digital Health Literacy and Attitudes Toward eHealth Technologies Among Patients With Cardiovascular Disease and Their Implications for Secondary Prevention: Survey Study

Cardiovascular disease remains the leading cause of global mortality, with coronary artery disease and ischemic heart disease alone contributing to 16% of total annual deaths worldwide [1]. Over the past 2 decades, ischemic heart disease has demonstrated the most rapid growth in overall death rates globally, resulting in nearly 9 million annual deaths [1]. Cardiovascular disease is intricately linked to various comorbidities and a severe mental health burden [2].

Greta Ullrich, Alexander Bäuerle, Hannah Vogt, Amir Abbas Mahabadi, Katrin Paldán, Daniel Messiha, Lisa Maria Jahre, Christos Rammos, Tienush Rassaf, Julia Lortz

JMIR Form Res 2025;9:e63057

Instagram Posts Promoting Colorectal Cancer Awareness: Content Analysis of Themes and Engagement During Colorectal Cancer Awareness Month

Instagram Posts Promoting Colorectal Cancer Awareness: Content Analysis of Themes and Engagement During Colorectal Cancer Awareness Month

Despite the clear benefits of early detection and screening for reducing mortality rates, many individuals remain unaware of the importance of regular screenings and the risk factors associated with CRC [3-5]. March is designated as Colorectal Cancer Awareness Month, a period dedicated to increasing public knowledge about CRC, promoting early detection and screening, and ultimately reducing the incidence and mortality of this disease [6].

Aditi Srivastava, Jim P Stimpson

JMIR Form Res 2025;9:e63344

Net Reproduction Number as a Real-Time Metric of Population Reproducibility

Net Reproduction Number as a Real-Time Metric of Population Reproducibility

The TFR does not account for mortality rates among childbearing-age women, possibly affecting population reproducibility [2,4]. These limitations reduce TFR’s ability to accurately reflect a country’s population replacement dynamics. Therefore, the net reproduction rate (Rt), the number of daughters a woman of childbearing age would produce under prevailing fertility and mortality conditions, is better.

Chiara Achangwa, Changhee Han, Jun-Sik Lim, Seonghui Cho, Sangbum Choi, Sukhyun Ryu

JMIR Public Health Surveill 2025;11:e63603

Machine Learning in the Management of Patients Undergoing Catheter Ablation for Atrial Fibrillation: Scoping Review

Machine Learning in the Management of Patients Undergoing Catheter Ablation for Atrial Fibrillation: Scoping Review

This contributes to long-term rises in both morbidity and mortality rates [8] as well as a growing strain on health care costs [9]. Catheter ablation (CA) represents the most effective clinical intervention currently available for AF [10]. When patients receive their first CA treatment, the effectiveness rate can reach 60%-80% within 1 year [11,12]. However, the long-term efficacy is not optimal , and the success rate decreases to 50%-60% at 3 to 5 years [13-15].

Aijing Luo, Wei Chen, Hongtao Zhu, Wenzhao Xie, Xi Chen, Zhenjiang Liu, Zirui Xin

J Med Internet Res 2025;27:e60888

Effectiveness of Continuous Glucose Monitoring on Short-Term, In-Hospital Mortality Among Frail and Critically Ill Patients With COVID-19: Randomized Controlled Trial

Effectiveness of Continuous Glucose Monitoring on Short-Term, In-Hospital Mortality Among Frail and Critically Ill Patients With COVID-19: Randomized Controlled Trial

Several reports indicate that diabetes and hyperglycemia are linked to worse morbidity and mortality in individuals with COVID-19 [9,10]. On the other hand, frail and critically ill patients with COVID-19 and previously normal glucose tolerance are also associated with variability in their glucose levels during their intensive care unit (ICU) stay, which might be caused by the critical illness itself or certain medication therapies such as glucocorticoids and immunosuppressants.

Jiawei Shang, Ziming Yuan, Zuoyan Zhang, Quanhong Zhou, Yan Zou, Wei Wang

J Med Internet Res 2025;27:e67012