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Effect of Continuous Positive Airway Pressure or Positional Therapy Compared to Control for Treatment of  Obstructive Sleep Apnea on the Development of Gestational Diabetes Mellitus in Pregnancy: Protocol for Feasibility Randomized Controlled Trial

Effect of Continuous Positive Airway Pressure or Positional Therapy Compared to Control for Treatment of Obstructive Sleep Apnea on the Development of Gestational Diabetes Mellitus in Pregnancy: Protocol for Feasibility Randomized Controlled Trial

During pregnancy, physiological changes, including upper airway edema and hormone-related upper airway pressure changes, predispose women to sleep-disordered breathing (SDB) [1]. The prevalence of obstructive sleep apnea (OSA) in pregnancy increases from 3.6% in early pregnancy to 8.3% in midpregnancy and is associated with an independent risk of gestational diabetes mellitus (GDM), preeclampsia, and hypertensive disorders of pregnancy (HDP) [2].

Frances Clements, Hima Vedam, Yewon Chung, John Smoleniec, Colin Sullivan, Renuka Shanmugalingam, Annemarie Hennessy, Angela Makris

JMIR Res Protoc 2025;14:e51434

Effects of Using a Smart Bassinet on the Mental Health of Military-Affiliated Pregnant Women: Protocol for a Randomized Controlled Sleep Health and Mood in Newly Expectant Military Mothers (SHINE) Trial

Effects of Using a Smart Bassinet on the Mental Health of Military-Affiliated Pregnant Women: Protocol for a Randomized Controlled Sleep Health and Mood in Newly Expectant Military Mothers (SHINE) Trial

Compare the trajectory of immune system function from late pregnancy through post partum between participants with and without PMADs and between SB and TB groups. (1) Hypothesis 3a: Peripheral cytokines, immune cells, and stimulated cytokine profiles of women with PMADs assessed in late pregnancy and at 3 and 6 months post partum will indicate greater innate immune activity compared to those of women without PMADs. (2) Hypothesis 3b: Mothers of infants who sleep in SB will exhibit lesser innate immune dysfunction

Michele L Okun, Jennifer L Payne, Lauren M Osborne, Leilani Feliciano, Andrew Lac

JMIR Res Protoc 2025;14:e66439

Experiences of Birth Attendants on Upward Obstetric Emergency Referrals in Low- and Middle-Income Countries: Protocol for a Scoping Review

Experiences of Birth Attendants on Upward Obstetric Emergency Referrals in Low- and Middle-Income Countries: Protocol for a Scoping Review

Pregnancy and childbirth can pose risks to both the mother and fetus [1], sometimes leading to life-threatening situations known as obstetric emergencies [2]. In such cases, specialized care is necessary and provided through a well-established referral system [3], typically an upward referral, which refers to the process by which health care providers at lower levels of the system seek assistance from specialized or better-equipped providers [4].

Final Z Juqu, Olivia B Baloyi, Esther L Mbobnda Kapche, Wilma ten Ham-Baloyi, Geldine Chironda, Zamadonda Nokuthula Xulu-Kasaba

JMIR Res Protoc 2025;14:e64886

Efficacy of a Personalized mHealth App in Improving Micronutrient Supplement Use Among Pregnant Women in Karachi, Pakistan: Parallel-Group Randomized Controlled Trial

Efficacy of a Personalized mHealth App in Improving Micronutrient Supplement Use Among Pregnant Women in Karachi, Pakistan: Parallel-Group Randomized Controlled Trial

Pregnancy involves profound physiological transformations, requiring optimal nutrition for fetal growth and maternal well-being [1]. Poor maternal nutrition can adversely affect the development, functioning, and programming of major fetal organs, leading to lifelong health consequences [2]. Micronutrients, including essential vitamins and minerals, are crucial for embryogenesis and placental and organ development, particularly during the early stage of pregnancy [2].

Khadija Vadsaria, Rozina Nuruddin, Nuruddin Mohammed, Iqbal Azam, Saleem Sayani

J Med Internet Res 2025;27:e67166

Automatic Human Embryo Volume Measurement in First Trimester Ultrasound From the Rotterdam Periconception Cohort: Quantitative and Qualitative Evaluation of Artificial Intelligence

Automatic Human Embryo Volume Measurement in First Trimester Ultrasound From the Rotterdam Periconception Cohort: Quantitative and Qualitative Evaluation of Artificial Intelligence

The current standard for monitoring growth and development during early pregnancy is the crown-rump length (CRL). Early measurements of the CRL are used in standard clinical practice to estimate gestational age. Moreover, CRL measurements can be used to predict miscarriages and are associated with estimated fetal weight, birth weight, and adverse pregnancy outcomes [1-5]. Volumetric measurements of the human embryo during early pregnancy are a novel way to assess growth and development.

Wietske A P Bastiaansen, Stefan Klein, Batoul Hojeij, Eleonora Rubini, Anton H J Koning, Wiro Niessen, Régine P M Steegers-Theunissen, Melek Rousian

J Med Internet Res 2025;27:e60887

Centering Birthing Experiences of Women of Color: Protocol for a Qualitative Maternal Near Miss Study

Centering Birthing Experiences of Women of Color: Protocol for a Qualitative Maternal Near Miss Study

Maternal health encompasses the well-being of both mothers and their newborns during pregnancy, childbirth, and the postpartum period. Despite advancements in medical technology and health care systems, there remain persistent challenges with maternal mortality (MM) and morbidity.

Kaitlyn Hernandez-Spalding, Oluyemi Farinu, Lasha Clarke, Tamiah Lewis, Angie Suarez, Kimarie Bugg, Kieauna Strickland, Ashley Molleti, Sherry Maxy, Natalie Hernandez-Green

JMIR Res Protoc 2025;14:e58410

Healthy Mom Zone Adaptive Intervention With a Novel Control System and Digital Platform to Manage Gestational Weight Gain in Pregnant Women With Overweight or Obesity: Study Design and Protocol for a Randomized Controlled Trial

Healthy Mom Zone Adaptive Intervention With a Novel Control System and Digital Platform to Manage Gestational Weight Gain in Pregnant Women With Overweight or Obesity: Study Design and Protocol for a Randomized Controlled Trial

High maternal prepregnancy BMI and high gestational weight gain (GWG) elevate the risks for poor pregnancy outcomes (eg, gestational diabetes and hypertension) and fetal outcomes (eg, large for gestational age birth weight) [1-6]. High BMI and GWG may also “program” the child’s metabolism for life [7,8] and increase the future risks for obesity and type 2 diabetes in both mothers and their offspring [1-6].

Danielle Symons Downs, Abigail M Pauley, Daniel E Rivera, Jennifer S Savage, Amy M Moore, Danying Shao, Sy-Miin Chow, Constantino Lagoa, Jaimey M Pauli, Owais Khan, Allen Kunselman

JMIR Res Protoc 2025;14:e66637

Evaluation of the MyFertiCoach Lifestyle App for Subfertile Couples: Single-Center Evaluation of Augmented Standard Care

Evaluation of the MyFertiCoach Lifestyle App for Subfertile Couples: Single-Center Evaluation of Augmented Standard Care

Reducing any or all of these lifestyle factors before pregnancy or assisted reproductive technology treatment can improve reproductive health [5-9]. In summary, the more negative lifestyle factors present, the lower the chance of becoming pregnant and the longer the time until pregnancy [10]. For instance, improving dietary patterns during the preconception period reduces the risk of several adverse birth outcomes, such as fetal growth restriction and babies born small or large for gestational age.

Jesper Smeenk, Ellen Smit, Marc Jacobs, Ilse van Rooij

JMIR Form Res 2025;9:e64239

Improving Maternal Mental Health and Weight Control With a Mindfulness Blended Care Approach: Insights From a Randomized Controlled Trial

Improving Maternal Mental Health and Weight Control With a Mindfulness Blended Care Approach: Insights From a Randomized Controlled Trial

In addition, each participating woman had weekly access to a self-developed digital pregnancy guide with educational and validated medical content focused on pregnancy and childbirth. The modules included for example the following topics: fears and worries about birth or parenting, coping with stress, birth-related pain control, and outlook puerperium.

Kathrin Hassdenteufel, Mitho Müller, Harald Abele, Sara Yvonne Brucker, Johanna Graf, Stephan Zipfel, Armin Bauer, Peter Jakubowski, Jan Pauluschke-Fröhlich, Markus Wallwiener, Stephanie Wallwiener

J Med Internet Res 2025;27:e56230

Evaluating the Quality, Content Accuracy, and User Suitability of mHealth Prenatal Care Apps for Expectant Mothers: Critical Assessment Study

Evaluating the Quality, Content Accuracy, and User Suitability of mHealth Prenatal Care Apps for Expectant Mothers: Critical Assessment Study

Pregnancy apps, in particular, have become popular resources for expectant mothers, offering functionalities ranging from fetal development tracking to health tips and educational content [6,7]. However, the reliability of health recommendations provided by pregnancy apps remains a significant concern.

Fateme Asadollahi, Samira Ebrahimzadeh Zagami, Saeid Eslami, Robab Latifnejad Roudsari

Asian Pac Isl Nurs J 2025;9:e66852