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Published on in Vol 6, No 2 (2017): February

Rationale and Design of a Genetic Study on Cardiometabolic Risk Factors: Protocol for the Tehran Cardiometabolic Genetic Study (TCGS)

Rationale and Design of a Genetic Study on Cardiometabolic Risk Factors: Protocol for the Tehran Cardiometabolic Genetic Study (TCGS)

Rationale and Design of a Genetic Study on Cardiometabolic Risk Factors: Protocol for the Tehran Cardiometabolic Genetic Study (TCGS)

Authors of this article:

Maryam S Daneshpour1 Author Orcid Image ;   Mohammad-Sadegh Fallah1 Author Orcid Image ;   Bahareh Sedaghati-Khayat1 Author Orcid Image ;   Kamran Guity1 Author Orcid Image ;   Davood Khalili2 Author Orcid Image ;   Mehdi Hedayati1 Author Orcid Image ;   Ahmad Ebrahimi1 Author Orcid Image ;   Farhad Hajsheikholeslami2 Author Orcid Image ;   Parvin Mirmiran3 Author Orcid Image ;   Fahimeh Ramezani Tehrani4 Author Orcid Image ;   Amir-Abbas Momenan2 Author Orcid Image ;   Arash Ghanbarian2 Author Orcid Image ;   Atieh Amouzegar5 Author Orcid Image ;   Parisa Amiri6 Author Orcid Image ;   Fereidoun Azizi5 Author Orcid Image
Article Authors Cited by (53) Tweetations (2) Metrics

Journals

  1. Javanrouh N, Khalaj A, Guity K, Sedaghati-khayat B, Valizadeh M, Barzin M, Daneshpour M. Presence of CC Genotype for rs17773430 Could Affect the Percentage of Excess Weight Loss 1 Year After Bariatric Surgery: Tehran Obesity Treatment Study (TOTS). Obesity Surgery 2020;30(2):537 View
  2. Azizi F. Tehran Lipid and Glucose Study: A National Legacy. International Journal of Endocrinology and Metabolism 2018;In Press(In Press) View
  3. Akbarzadeh M, Moghimbeigi A, Morris N, Daneshpour M, Mahjub H, Soltanian A. A Bayesian structural equation model in general pedigree data analysis. Statistical Analysis and Data Mining: The ASA Data Science Journal 2019;12(5):404 View
  4. Daneshpour M, Hedayati M, Sedaghati-Khayat B, Guity K, Zarkesh M, Akbarzadeh M, Javanrooh N, Zadeh-Vakili A, Azizi F. Cardio-Metabolic Disease Genetic Risk Factors in Iran: Twenty Years of Tehran Lipid and Glucose Study. International Journal of Endocrinology and Metabolism 2018;In Press(In Press) View
  5. Piri Z, Barzin M, Mahdavi M, Guity K, Azizi F, Hosseinpanah F, Valizadeh M. The role of childhood BMI in predicting early adulthood dysglycemia: Tehran lipid and glucose study. Nutrition, Metabolism and Cardiovascular Diseases 2020;30(2):313 View
  6. Sedaghati-khayat B, Barzin M, Akbarzadeh M, Guity K, Fallah M, Pourhassan H, Azizi F, Daneshpour M. Lack of association between FTO gene variations and metabolic healthy obese (MHO) phenotype: Tehran Cardio-metabolic Genetic Study (TCGS). Eating and Weight Disorders - Studies on Anorexia, Bulimia and Obesity 2020;25(1):25 View
  7. Koochakpour G, Esfandiar Z, Hosseini-Esfahani F, Mirmiran P, Daneshpour M, Sedaghati-Khayat B, Azizi F. Evaluating the interaction of common FTO genetic variants, added sugar, and trans-fatty acid intakes in altering obesity phenotypes. Nutrition, Metabolism and Cardiovascular Diseases 2019;29(5):474 View
  8. Moazzam-Jazi M, Najd Hassan Bonab L, Zahedi A, Daneshpour M. High genetic burden of type 2 diabetes can promote the high prevalence of disease: a longitudinal cohort study in Iran. Scientific Reports 2020;10(1) View
  9. Ramezankhani A, Guity K, Azizi F, Hadaegh F. Sex differences in the association between spousal metabolic risk factors with incidence of type 2 diabetes: a longitudinal study of the Iranian population. Biology of Sex Differences 2019;10(1) View
  10. Khalili D, Azizi F, Asgari S, Zadeh-Vakili A, Momenan A, Ghanbarian A, Eskandari F, Sheikholeslami F, Hadaegh F. Outcomes in the Tehran Lipid and Glucose Study (TLGS) as a Longitudinal Population-Based Cohort Study and a Pragmatic Community Trial. International Journal of Endocrinology and Metabolism 2018;In Press(In Press) View
  11. Ramezankhani A, Guity K, Azizi F, Hadaegh F. Spousal metabolic risk factors and future cardiovascular events: A prospective cohort study. Atherosclerosis 2020;298:36 View
  12. Jabbari F, Mohseni Bandpei A, Daneshpour M, Shahsavani A, Hashemi Nazari S, Faraji Sabokbar H, Momenan A, Azizi F. Role of Air Pollution and rs10830963 Polymorphism on the Incidence of Type 2 Diabetes: Tehran Cardiometabolic Genetic Study. Journal of Diabetes Research 2020;2020:1 View
  13. Styrkarsdottir U, Helgason H, Sigurdsson A, Norddahl G, Agustsdottir A, Reynard L, Villalvilla A, Halldorsson G, Jonasdottir A, Magnusdottir A, Oddson A, Sulem G, Zink F, Sveinbjornsson G, Helgason A, Johannsdottir H, Helgadottir A, Stefansson H, Gretarsdottir S, Rafnar T, Almdahl I, Brækhus A, Fladby T, Selbæk G, Hosseinpanah F, Azizi F, Koh J, Tang N, Daneshpour M, Mayordomo J, Welt C, Braund P, Samani N, Kiemeney L, Lohmander L, Christiansen C, Andreassen O, Magnusson O, Masson G, Kong A, Jonsdottir I, Gudbjartsson D, Sulem P, Jonsson H, Loughlin J, Ingvarsson T, Thorsteinsdottir U, Stefansson K. Whole-genome sequencing identifies rare genotypes in COMP and CHADL associated with high risk of hip osteoarthritis. Nature Genetics 2017;49(5):801 View
  14. Javanrouh N, Soltanian A, Tapak L, Azizi F, Ott J, Daneshpour M. A novel association of rs13334070 in the RPGRIP1L gene with adiposity factors discovered by joint linkage and linkage disequilibrium analysis in Iranian pedigrees: Tehran Cardiometabolic Genetic Study (TCGS). Genetic Epidemiology 2019;43(3):342 View
  15. Ramezankhani A, Guity K, Azizi F, Hadaegh F. Spousal metabolic risk factors and incident hypertension: A longitudinal cohort study in Iran. The Journal of Clinical Hypertension 2020;22(1):95 View
  16. Gharooi Ahangar O, Javanrouh N, Daneshpour M, Barzin M, Valizadeh M, Azizi F, Hosseinpanah F. Genetic markers and continuity of healthy metabolic status: Tehran cardio-metabolic genetic study (TCGS). Scientific Reports 2020;10(1) View
  17. Hosseini-Esfahani F, Koochakpoor G, Mirmiran P, Daneshpour M, Azizi F. Dietary patterns modify the association between fat mass and obesity-associated genetic variants and changes in obesity phenotypes. British Journal of Nutrition 2019;121(11):1247 View
  18. Hosseinzadeh N, Mehrabi Y, Daneshpour M, Zayeri F, Guity K, Azizi F. Identifying new associated pleiotropic SNPs with lipids by simultaneous test of multiple longitudinal traits: An Iranian family-based study. Gene 2019;692:156 View
  19. Ramezankhani A, Harati H, Bozorgmanesh M, Tohidi M, Khalili D, Azizi F, Hadaegh F. Diabetes Mellitus: Findings from 20 Years of the Tehran Lipid and Glucose Study. International Journal of Endocrinology and Metabolism 2018;16(Suppl Issue) View
  20. Lanjanian H, Moazzam-Jazi M, Hedayati M, Akbarzadeh M, Guity K, Sedaghati-khayat B, Azizi F, Daneshpour M. SARS-CoV-2 infection susceptibility influenced by ACE2 genetic polymorphisms: insights from Tehran Cardio-Metabolic Genetic Study. Scientific Reports 2021;11(1) View
  21. Hosseinpour-Niazi S, Bakhshi B, Zahedi A, Akbarzadeh M, Daneshpour M, Mirmiran P, Azizi F. TCF7L2 polymorphisms, nut consumption, and the risk of metabolic syndrome: a prospective population based study. Nutrition & Metabolism 2021;18(1) View
  22. Javanrouh Givi N, Najd Hassan Bonab L, Barzin M, Zahedi A, Sedaghati-khayat B, Akbarzadeh M, Daneshpour M. The joint effect of PPARG upstream genetic variation in association with long-term persistent obesity: Tehran cardio-metabolic genetic study (TCGS). Eating and Weight Disorders - Studies on Anorexia, Bulimia and Obesity 2021;26(7):2325 View
  23. Akbarzadeh M, Dehkordi S, Roudbar M, Sargolzaei M, Guity K, Sedaghati-khayat B, Riahi P, Azizi F, Daneshpour M. GWAS findings improved genomic prediction accuracy of lipid profile traits: Tehran Cardiometabolic Genetic Study. Scientific Reports 2021;11(1) View
  24. Zahedi A, Akbarzadeh M, Sedaghati-Khayat B, Seyedhamzehzadeh A, Daneshpour M. GCKR common functional polymorphisms are associated with metabolic syndrome and its components: a 10-year retrospective cohort study in Iranian adults. Diabetology & Metabolic Syndrome 2021;13(1) View
  25. Kolifarhood G, Daneshpour M, Zahedi A, Khosravi N, Sedaghati-Khayat B, Guity K, Rasekhi Dehkordi S, Amiri Roudbar M, Ghanbari F, Hadaegh F, Azizi F, Akbarzadeh M, Sabour S. Familial genetic and environmental risk profile and high blood pressure event: a prospective cohort of cardio-metabolic and genetic study. Blood Pressure 2021;30(3):196 View
  26. Goodarzi G, Hosseini-Esfahani F, Ataie-Jafari A, Haji-Hosseini-gazestani N, Daneshpour M, Keshavarz S, Mirmiran P. Dietary diversity modifies the association between FTO polymorphisms and obesity phenotypes. International Journal of Food Sciences and Nutrition 2021;72(7):997 View
  27. Najd Hassan Bonab L, Moazzam-Jazi M, Miri Moosavi R, Fallah M, Lanjanian H, Masjoudi S, Daneshpour M. Low HDL concentration in rs2048327-G carriers can predispose men to develop coronary heart disease: Tehran Cardiometabolic genetic study (TCGS). Gene 2021;778:145485 View
  28. Masjoudi S, Sedaghati-khayat B, Givi N, Bonab L, Azizi F, Daneshpour M. Kernel machine SNP set analysis finds the association of BUD13, ZPR1, and APOA5 variants with metabolic syndrome in Tehran Cardio-metabolic Genetics Study. Scientific Reports 2021;11(1) View
  29. Kolifarhood G, Sabour S, Akbarzadeh M, Sedaghati-khayat B, Guity K, Rasekhi Dehkordi S, Amiri Roudbar M, Hadaegh F, Azizi F, Daneshpour M. Genome-wide association study on blood pressure traits in the Iranian population suggests ZBED9 as a new locus for hypertension. Scientific Reports 2021;11(1) View
  30. Akbarzadeh M, Alipour N, Moheimani H, Zahedi A, Hosseini-Esfahani F, Lanjanian H, Azizi F, Daneshpour M. Evaluating machine learning-powered classification algorithms which utilize variants in the GCKR gene to predict metabolic syndrome: Tehran Cardio-metabolic Genetics Study. Journal of Translational Medicine 2022;20(1) View
  31. Akbarzadeh M, Riahi P, Kolifarhood G, Lanjanian H, Alipour N, Najd Hassan Bonab L, Reza Moghadas M, Sabour S, Azizi F, Daneshpour M. The AGT epistasis pattern proposed a novel role for ZBED9 in regulating blood pressure: Tehran Cardiometabolic genetic study (TCGS). Gene 2022;831:146560 View
  32. Lanjanian H, Najd Hassan Bonab L, Akbarzadeh M, Moazzam-Jazi M, Zahedi A, Masjoudi S, Daneshpour M. Sex, age, and ethnic dependency of lipoprotein variants as the risk factors of ischemic heart disease: a detailed study on the different age-classes and genders in Tehran Cardiometabolic Genetic Study (TCGS). Biology of Sex Differences 2022;13(1) View
  33. Najd-Hassan-Bonab L, Safarpour M, Moazzam-Jazi M, Azizi F, Daneshpour M. The role of FTO variant rs1421085 in the relationship with obesity: a systematic review and meta-analysis. Eating and Weight Disorders - Studies on Anorexia, Bulimia and Obesity 2022;27(8):3053 View
  34. Moradi S, Alivand M, KhajeBishak Y, AsghariJafarabadi M, Alipour M, faghfouri A, Alipour B. The Effect of ω3 Fatty Acids Supplementation on Levels of PPARγ and UCP2 Genes Expression, Serum Level of UCP2 Protein, Metabolic Status, and Appetite in Elite male Athletes: Protocol for a Randomized Control Trial. International Journal of Surgery: Protocols 2021;25(1):184 View
  35. Hosseinpour-Niazi S, Mirmiran P, Hadaegh F, Mahdavi M, Khalili D, Daneshpour M, Momenan A, Azizi F. Improvement of glycemic indices by a hypocaloric legume-based DASH diet in adults with type 2 diabetes: a randomized controlled trial. European Journal of Nutrition 2022;61(6):3037 View
  36. Moazzam-Jazi M, Najd-Hassan-Bonab L, Masjoudi S, Tohidi M, Hedayati M, Azizi F, Daneshpour M. Risk of type 2 diabetes and KCNJ11 gene polymorphisms: a nested case–control study and meta-analysis. Scientific Reports 2022;12(1) View
  37. Akbarzadeh M, Riahi P, Ramezankhani A, Dehkordi S, Roudbar M, Zarkesh M, Guity K, Khalili D, Zahedi A, Azizi F, Daneshpour M. Parental Transmission Plays the Major Role in High Aggregation of Type 2 Diabetes in Iranian Families: Tehran Lipid and Glucose Study. Canadian Journal of Diabetes 2022;46(1):60 View
  38. Zeinalian R, Arman Moghadam D, Pahlavani N, Roshanravan N, Alizadeh M, Jabbari M, Kheirouri S. Investigation of the association between cardio-metabolic risk factors, neurotrophins and gastric hormones among apparently healthy women: A cross-sectional analysis. Journal of Cardiovascular and Thoracic Research 2022;14(1):53 View
  39. Moazzam-Jazi M, Sadat Zahedi A, Akbarzadeh M, Azizi F, Daneshpour M. Diverse effect of MC4R risk alleles on obesity-related traits over a lifetime: Evidence from a well-designed cohort study. Gene 2022;807:145950 View
  40. Ghanooni A, Zadeh-Vakili A, Rezvankhah B, Jafari Nodushan S, Akbarzadeh M, Amouzegar A, Daneshpour M, Khalili D, Mehrabi Y, Ebadi S, Azizi F. Longitudinal Associations Between TPO Gene Variants and Thyroid Peroxidase Antibody Seroconversion in a Population-Based Study: Tehran Thyroid Study. Genetic Testing and Molecular Biomarkers 2023;27(3):65 View
  41. Lajevardi S, Kargari M, Daneshpour M, Akbarzadeh M. Hypertension Risk Prediction Based on SNPs by Machine Learning Models. Current Bioinformatics 2023;18(1):55 View
  42. Daneshpour M, Akbarzadeh M, Lanjanian H, Sedaghati-khayat B, Guity K, Masjoudi S, Zahedi A, Moazzam-Jazi M, Bonab L, Shalbafan B, Asgarian S, Farhood G, Javanrooh N, Zarkesh M, Riahi P, Moghaddas M, Dehkordi P, Ahmadi A, Hosseini F, Farahani S, Hadaegh F, Mirmiran P, Tehrani F, Ghanbarian A, Pasand M, Amiri P, Valizadeh M, Hosseipanah F, Tohidi M, Ghasemi A, Zadeh-Vakili A, Piryaei M, Alamdari S, Khalili D, Momenan A, Barzin M, Zeinali S, Hedayati M, Azizi F. Cohort profile update: Tehran cardiometabolic genetic study. European Journal of Epidemiology 2023;38(6):699 View
  43. Teymoori F, Akbarzadeh M, Farhadnejad H, Riahi P, Mokhtari E, Ahmadirad H, Zahedi A, Hosseini-Esfahani F, Zarkesh M, Daneshpour M, Mirmiran P, Vafa M. Familial resemblance and family-based heritability of nutrients intake in Iranian population: Tehran cardiometabolic genetic study. BMC Public Health 2023;23(1) View
  44. Hosseini-Esfahani F, Rezaei M, Koochakpoor G, Daneshpour M, Mirmiran P, Azizi F. Dietary approach to stop hypertension and healthy eating index 2015, modify the association between FTO polymorphisms and obesity phenotypes. BMC Research Notes 2023;16(1) View
  45. Asghari G, Yuzbashian E, Najd-Hassan-Bonab L, Mirmiran P, Daneshpour M, Azizi F. Association of rs2282679 polymorphism in vitamin D binding protein gene (GC) with the risk of vitamin D deficiency in an iranian population: season-specific vitamin D status. BMC Endocrine Disorders 2023;23(1) View
  46. Akbarzadeh M, Teymoori F, Riahi P, Farhadnejad H, Ahmadirad H, Sadat Zahedi A, Hosseini-Esfahani F, Zarkesh M, Vafa M, Mirmiran P, Daneshpour M. Evidence of familial resemblance and family-based heritability of food intakes derived from a longitudinal cohort study. Scientific Reports 2023;13(1) View
  47. Najd-Hassan-Bonab L, Hedayati M, Shahzadeh Fazeli S, Daneshpour M. An optimized method for PCR-based genotyping to detect human APOE polymorphisms. Heliyon 2023;9(11):e21102 View
  48. Zadeh-Vakili A, Najd-Hassan-Bonab L, Akbarzadeh M, Abdi H, Zahedi A, Azizi F, Daneshpour M. Three candidate SNPs show associations with thyroid-stimulating hormone in euthyroid subjects: Tehran thyroid study. Journal of Diabetes & Metabolic Disorders 2024;23(1):1047 View
  49. Rezaeizadeh F, Ghazbani A, Nouri M, Bahadoran Z, Mansourzadeh M, Khalili D. Bibliometric overview of the Tehran Lipid and Glucose Study (TLGS) publications from 2000 to 2022. Journal of Diabetes & Metabolic Disorders 2024;23(1):343 View
  50. Akbarzadeh M, Riahi P, Saeidian A, Zarkesh M, Masjoudi S, Asgarian S, Guity K, Moheimani H, Masoudi H, Roudbar M, Khalili D, Hosseinpanah F, Barzin M, Hogan C, Hakonarson H, Hedayati M, Daneshpour M, Azizi F. The Tehran longitudinal family-based cardiometabolic cohort study sheds new light on dyslipidemia transmission patterns. Scientific Reports 2024;14(1) View
  51. Asgarian S, Lanjanian H, Rahimipour Anaraki S, Hadaegh F, Moazzam-Jazi M, Najd-Hassan-Bonab L, Masjoudi S, Zahedi A, Zarkesh M, Shalbafan B, Akbarzadeh M, Tehrani Fateh S, Khalili D, Momenan A, Sarbazi N, Hedayati M, Azizi F, Daneshpour M. Examining the clinical and genetic spectrum of maturity-onset diabetes of the young (MODY) in Iran. Scientific Reports 2024;14(1) View
  52. Amiri Roudbar M, Vahedi S, Jin J, Jahangiri M, Lanjanian H, Habibi D, Masjoudi S, Riahi P, Fateh S, Neshati F, Zahedi A, Moazzam-Jazi M, Najd-Hassan-Bonab L, Mousavi S, Asgarian S, Zarkesh M, Moghaddas M, Tenesa A, Kazemnejad A, Vahidnezhad H, Hakonarson H, Azizi F, Hedayati M, Daneshpour M, Akbarzadeh M. The effect of family structure on the still-missing heritability and genomic prediction accuracy of type 2 diabetes. Human Genomics 2024;18(1) View
  53. Teymoori F, Saber N, Akbarzadeh M, Farhadnejad H, Mokhtari E, Ahmadirad H, Riahi P, Mirmiran P, Daneshpour M, Azizi F. The trend of correlation changes of macronutrient intakes among different familial pairs: a prospective study among participants of Tehran Lipid and Glucose Study. BMC Public Health 2024;24(1) View