Bioengineered Temporomandibular Joint Disk Implants: Study Protocol for a Two-Phase Exploratory Randomized Preclinical Pilot Trial in 18 Black Merino Sheep (TEMPOJIMS)

David Faustino Ângelo   ^{1, 2, 3} , MD ;   Florencio Gil Monje   ⁴ , MD, PhD ;   Raúl González-García   ⁴ , MD, PhD ;   Christopher B Little   ⁵ , MVM, PhD ;   Lisete Mónico   ⁶ , PhD ;   Mário Pinho   ⁷ , MVM, PhD ;   Fábio Abade Santos   ⁷ ;   Belmira Carrapiço   ⁸ , MVM ;   Sandra Cavaco Gonçalves   ⁹ , MVM ;   Pedro Morouço   ² , PhD ;   Nuno Alves   ² , MEng, PhD ;   Carla Moura   ² , MEng (Biomed Eng), PhD ;   Yadong Wang   ¹⁰ , MEng (Biomed Eng), PhD ;   Eric Jeffries   ¹⁰ , MEng (Biomed Eng), PhD ;   Jin Gao   ¹⁰ , MEng (Biomed Eng), PhD ;   Rita Sousa   ³ , MD ;   Lia Lucas Neto   ³ , MD, PhD ;   Daniel Caldeira   ³ , MD ;   Francisco Salvado   ³ , MD, PhD

¹ Centro Hospitalar de Setúbal, EPE, Stomatology Department, Setúbal, Portugal

² Instituto Politécnico de Leiria, Centre for Rapid and Sustainable Product Development (CDRSP), Leiria, Portugal

³ Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal

⁴ University Hospital Infanta Cristina, Badajoz, Spain, Department of Oral and Maxillofacial Surgery, Badajoz, Spain

⁵ Kolling Institute, Institute of Bone and Joint Research, University of Sydney, Sydney, Australia

⁶ Coimbra University, Coimbra, Portugal

⁷ Faculdade de Medicina Veterinaria, Interdisciplinary Centre of Research in Animal Health (CIISA), Lisbon University, Lisboa, Portugal

⁸ Faculdade de Medicina Veterinaria, Lisbon University, Lisboa, Portugal

⁹ Instituto Nacional de Investigação Agrária e Veterinária (INIAV I.P.), Santarém, Portugal

¹⁰ University of Pittsburgh, Chemical Engineering and Surgery Pittsburgh, University of Pittsburgh, Pittsburgh, PA, United States