A Fully Integrated Real-Time Detection, Diagnosis, and Control of Community Diarrheal Disease Clusters and Outbreaks (the INTEGRATE Project): Protocol for an Enhanced Surveillance System

Kirsty Marie McIntyre   ^{1, 2} , BSc, PhD ;   Frederick J Bolton   ¹ , PhD ;   Rob M Christley   ¹ , PhD ;   Paul Cleary   ^{2, 3} , MD, PhD ;   Elizabeth Deja   ⁴ , PhD ;   Ann E Durie   ¹ , MSc ;   Peter J Diggle   ^{2, 5} , PhD ;   Dyfrig A Hughes   ⁶ , PhD ;   Simon de Lusignan   ^{7, 8} , MD ;   Lois Orton   ⁴ , PhD ;   Alan D Radford   ⁹ , PhD ;   Alex J Elliot   ¹⁰ , PhD ;   Gillian E Smith   ¹⁰ , MD ;   Darlene A Snape   ⁴ , PhD ;   Debbi Stanistreet   ⁴ , PhD ;   Roberto Vivancos   ³ , MD, PhD ;   Craig Winstanley   ¹¹ , PhD ;   Sarah J O’Brien   ^{2, 4} , MD

¹ Department of Epidemiology and Population Health, Institute of Infection and Global Health, University of Liverpool, Neston, GB

² National Institute for Health Research Health Protection Research Unit in Gastrointestinal Infections, Liverpool, GB

³ Field Epidemiology Services, Public Health England, Liverpool, GB

⁴ Department of Public Health and Policy, Institute of Psychology, Health and Society, University of Liverpool, Liverpool, GB

⁵ Centre for Health Informatics, Computing, and Statistics, Lancaster Medical School, Lancaster University, Lancaster, GB

⁶ Centre for Health Economics and Medicines Evaluation, Bangor University, Bangor, GB

⁷ Royal College of General Practitioners Research and Surveillance Centre, London, GB

⁸ Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, GB

⁹ Department of Infection Biology, Institute of Infection and Global Health, University of Liverpool, Neston, GB

¹⁰ Real-Time Syndromic Surveillance Team, Field Service, National Infection Service, Public Health England, Birmingham, GB

¹¹ Department of Clinical Infection, Microbiology and Immunology, Institute of Infection and Global Health, University of Liverpool, Liverpool, GB