Comparing the Effectiveness of Education Versus Digital Cognitive Behavioral Therapy for Adults With Sickle Cell Disease: Protocol for the Cognitive Behavioral Therapy and Real-time Pain Management Intervention for Sickle Cell via Mobile Applications (CaRISMA) Study

Sherif M Badawy   ^{1, 2} , MD, MS ;   Kaleab Z Abebe   ³ , PhD ;   Charlotte A Reichman   ³ , MA ;   Grace Checo   ³ , BA ;   Megan E Hamm   ³ , PhD ;   Jennifer Stinson   ⁴ , PhD, CPNP, RN-EC ;   Chitra Lalloo   ^{5, 6} , BHSc, PhD ;   Patrick Carroll   ⁷ , MD ;   Santosh L Saraf   ⁸ , MD ;   Victor R Gordeuk   ⁸ , MD ;   Payal Desai   ⁹ , MD ;   Nirmish Shah   ^{10, 11} , MD ;   Darla Liles   ¹² , MD ;   Cassandra Trimnell   ¹³ , BA ;   Charles R Jonassaint   ^{3, 14} , MHS, PhD

¹ Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, IL, United States

² Division of Hematology, Oncology and Stem Cell, Ann & Robert H Lurie Children's Hospital of Chicago, Chicago, IL, United States

³ Department of Medicine, University of Pittsburgh, Pittsburgh, PA, United States

⁴ Child Health Evaluative Sciences, Hospital for Sick Children, Lawrence S Bloomberg Faculty of Nursing, University of Toronto, Toronto, ON, Canada

⁵ Child Health Evaluation Sciences, Hospital for Sick Children, Toronto, ON, Canada

⁶ Institute for Health Policy, Management & Evaluation, University of Toronto, Toronto, ON, Canada

⁷ Johns Hopkins Sickle Cell Center for Adults, Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD, United States

⁸ Sickle Cell Center, Department of Medicine, University of Illinois at Chicago, Chicago, IL, United States

⁹ Ohio State Adult Sickle Cell Program, Division of Hematology, Ohio State University, Columbus, OH, United States

¹⁰ Division of Hematology, Duke University School of Medicine, Durham, NC, United States

¹¹ Division of Pediatric Hematology/Oncology, Duke University School of Medicine, Durham, NC, United States

¹² Department of Internal Medicine, East Carolina University, Greenville, NC, United States

¹³ Sickle Cell 101, San Jose, CA, United States

¹⁴ Center for Research on Media, Technology, and Health, University of Pittsburgh, Pittsburgh, PA, United States