Directly Observed Therapy to Measure Adherence to Tuberculosis Medication in Observational Research: Protocol for a Prospective Cohort Study

Elizabeth J Ragan   ¹ , MPH ;   Christopher J Gill   ² , MD ;   Matthew Banos   ² , MPH ;   Tara C Bouton   ¹ , MPH&TM, MD ;   Jennifer Rooney   ¹ , MSc ;   Charles R Horsburgh   ^{1, 2, 3} , MD ;   Robin M Warren   ⁴ , PhD ;   Bronwyn Myers   ^{5, 6} , PhD ;   Karen R Jacobson   ¹ , MPH, MD

¹ Section of Infectious Diseases, Boston Medical Center, Boston, MA, United States

² Department of Global Health, Boston University School of Public Health, Boston, MA, United States

³ Departments of Epidemiology and Biostatistics, Boston University School of Public Health, Boston, MA, United States

⁴ Department of Science and Innovation–The National Research Foundation Centre of Excellence for Biomedical Tuberculosis Research and The South African Medical Research Council Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa

⁵ Alcohol, Tobacco and Other Drug Research Unit, South African Medical Research Council, Cape Town, South Africa

⁶ Division of Addiction Psychiatry, Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa