Administration of Parenteral Vitamin C in Patients With Severe Infection: Protocol for a Systematic Review and Meta-analysis

Arnav Agarwal   ¹ , MD ;   John Basmaji   ² , MD ;   Shannon M Fernando   ^{3, 4} , MD, MSc ;   Fang Zhou Ge   ⁵ , BSc ;   Yingqi Xiao   ^{6, 7} , MSN, PhD ;   Haseeb Faisal   ⁸ , BHSc ;   Kimia Honarmand   ² , MD, MSc ;   Mathieu Hylands   ⁹ , MDCM, MSc ;   Vincent I Lau   ¹⁰ , MD, MSc ;   Kimberley Lewis   ¹¹ , MD, MSc ;   Rachel Couban   ¹² , MISt ;   François Lamontagne   ^{13, 14 *} , MD, MSc ;   Neill KJ Adhikari   ^{9, 15 *} , MDCM, MSc

¹ Division of General Internal Medicine, Department of Medicine, McMaster University, Hamilton, ON, Canada

² Division of Critical Care, Department of Medicine, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada

³ Division of Critical Care, Department of Medicine, University of Ottawa, Ottawa, ON, Canada

⁴ Department of Emergency Medicine, University of Ottawa, Ottawa, ON, Canada

⁵ Michael G DeGroote School of Medicine, McMaster University, Hamilton, ON, Canada

⁶ Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, ON, Canada

⁷ Department of Nursing, West China School of Nursing, West China Hospital, Sichuan University, Chengdu, China

⁸ Faculty of Medicine, McMaster University, Hamilton, ON, Canada

⁹ Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, ON, Canada

¹⁰ Department of Critical Care Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada

¹¹ Department of Medicine, McMaster University, Hamilton, ON, Canada

¹² Department of Anesthesia, McMaster University, Hamilton, ON, Canada

¹³ Department of Medicine, Université de Sherbrooke, Sherbrooke, QC, Canada

¹⁴ Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, QC, Canada

¹⁵ Department of Critical Care Medicine, Sunnybrook Health Sciences Centre, Toronto, ON, Canada

*these authors contributed equally