The Fetal Growth Restriction at Term Managed by Angiogenic Factors Versus Feto-Maternal Doppler (GRAFD) Trial to Avoid Adverse Perinatal Outcomes: Protocol for a Multicenter, Open-Label, Randomized Controlled Trial

Pablo Garcia-Manau   ^{1 *} , MD ;   Manel Mendoza   ^{1 *} , MD, PhD ;   Erika Bonacina   ¹ , MD ;   Raquel Martin-Alonso   ^{2, 3} , MD ;   Lourdes Martin   ⁴ , MD ;   Ana Palacios   ^{5, 6} , MD, PhD ;   Maria Luisa Sanchez   ⁷ , MD ;   Cristina Lesmes   ⁸ , MD, PhD ;   Ivan Hurtado   ⁹ , MD ;   Esther Perez   ¹⁰ , MD ;   Albert Tubau   ¹¹ , MD ;   Patricia Ibañez   ¹² , MD ;   Marina Alcoz   ¹³ , MD ;   Nuria Valiño   ¹⁴ , MD, PhD ;   Elena Moreno   ¹⁵ , MD ;   Carlota Borrero   ¹⁶ , MD, PhD ;   Esperanza Garcia   ¹⁷ , MD ;   Eva Lopez-Quesada   ¹⁸ , MD, PhD ;   Sonia Diaz   ¹⁹ , MD ;   Jose Roman Broullon   ²⁰ , MD, PhD ;   Mireia Teixidor   ²¹ , MD ;   Carolina Chulilla   ²² , MD ;   Maria M Gil   ^{2, 3} , MD, PhD ;   Monica Lopez   ⁴ , MD ;   Amparo Candela-Hidalgo   ^{5, 6} , MD ;   Andrea Salinas-Amoros   ⁷ , MD ;   Anna Moreno   ⁸ , MD ;   Francesca Morra   ⁹ , MD ;   Oscar Vaquerizo   ¹⁰ , MD ;   Beatriz Soriano   ¹¹ , MD ;   Marta Fabre   ¹² , MD ;   Elena Gomez-Valencia   ¹³ , MD ;   Ana Cuiña   ¹⁴ , MD ;   Nicolas Alayon   ¹⁵ , MD ;   Jose Antonio Sainz   ¹⁶ , MD, PhD ;   Angels Vives   ¹⁷ , MD ;   Esther Esteve   ¹⁸ , MD ;   Vanesa Ocaña   ¹⁹ , MD ;   Miguel Ángel López   ²⁰ , MD, PhD ;   Anna Maroto   ²¹ , MD, PhD ;   Elena Carreras   ¹ , MD, PhD

¹ Maternal Fetal Medicine Unit, Department of Obstetrics, Vall d’Hebron Barcelona Hospital Campus, Universitat Autònoma de Barcelona, Barcelona, Spain

² Maternal Fetal Medicine Unit, Department of Obstetrics, Hospital Universitario de Torrejón, Madrid, Spain

³ School of Medicine, Universidad Francisco de Vitoria, Madrid, Spain

⁴ Maternal Fetal Medicine Unit, Department of Obstetrics, Hospital Universitari de Tarragona Joan XXIII, Universitat Rovira i Virgili, Tarragona, Spain

⁵ Department of Obstetrics, Alicante University General Hospital, Miguel Hernandez University, Alicante, Spain

⁶ Alicante Institute for Health and Biomedical Research, Alicante, Spain

⁷ Maternal Fetal Medicine Unit, Department of Obstetrics, Hospital Clínico Universitario Virgen de la Arrixaca, Universidad de Murcia, Murcia, Spain

⁸ Maternal Fetal Medicine Unit, Department of Obstetrics, Parc Taulí Hospital Universitari, Universitat Autònoma de Barcelona, Sabadell, Spain

⁹ Maternal Fetal Medicine Unit, Department of Obstetrics, Hospital Universitari Germans Trias i Pujol, Universitat Autònoma de Barcelona, Badalona, Spain

¹⁰ Maternal Fetal Medicine Unit, Department of Obstetrics, Hospital Universitario de Cabueñes, Universidad de Oviedo, Gijón, Spain

¹¹ Maternal Fetal Medicine Unit, Department of Obstetrics, Hospital Universitari Son Llàtzer, Universitat de les Illes Balears, Palma de Mallorca, Spain

¹² Aragon Institute for Health Research, Department of Obstetrics, Hospital Clínico Universitario Lozano Blesa, Zaragoza, Spain

¹³ Maternal Fetal Medicine Unit, Department of Obstetrics, Fundació Althaia, Universitat de Vic, Manresa, Spain

¹⁴ Maternal Fetal Medicine Unit, Department of Obstetrics, Hospital Universitario de A Coruña, Universidade da Coruña, A Coruña, Spain

¹⁵ Maternal Fetal Medicine Unit, Department of Obstetrics, Hospital General Universitario de Elche, Universidad Miguel Hernández, Elche, Spain

¹⁶ Maternal Fetal Medicine Unit, Department of Obstetrics, Hospital Universitario Virgen de Valme, Universidad de Sevilla, Sevilla, Spain

¹⁷ Maternal Fetal Medicine Unit, Department of Obstetrics, Consorci Sanitari de Terrassa, Universitat Internacional de Catalunya, Terrassa, Spain

¹⁸ Maternal Fetal Medicine Unit, Department of Obstetrics, Hospital Universitari Mútua Terrassa, Universitat de Barcelona, Terrassa, Spain

¹⁹ Maternal Fetal Medicine Unit, Department of Obstetrics, Hospital Universitario de Getafe, Universidad Europea de Madrid, Getafe, Spain

²⁰ Maternal Fetal Medicine Unit, Department of Obstetrics, Hospital Universitario Puerta del Mar, Universidad de Cádiz, Cádiz, Spain

²¹ Maternal Fetal Medicine Unit, Department of Obstetrics, Hospital Universitari de Girona Doctor Josep Trueta, Universitat de Girona, Girona, Spain

²² Maternal Fetal Medicine Unit, Department of Obstetrics, Hospital Universitario Nuestra Señora de Candelaria, Universidad de La Laguna, Santa Cruz de Tenerife, Spain

*these authors contributed equally