Investigating Genetic and Other Determinants of First-Onset Myocardial Infarction in Malaysia: Protocol for the Malaysian Acute Vascular Events Risk Study

Rajiv Chowdhury   ^{1, 2} , MBBS, MPhil, PhD ;   Mohd Fairulnizal Md Noh   ³ , BSc, MSc, PhD ;   Sophia Rasheeqa Ismail   ³ , MBBS, MSc ;   Kim Robin van Daalen   ¹ , BSc, MPhil ;   Puteri Sofia Nadira Megat Kamaruddin   ³ , MBBS, MPH ;   Siti Hafizah Zulkiply   ³ , MD, MPH ;   Nur Hayati Azizul   ³ , MBBS ;   Norhayati Mustafa Khalid   ³ , BSc, MSc ;   Azizan Ali   ³ , MBBS, MSc ;   Izyan Mohd Idris   ³ , BAO, BCh, MB, MSc ;   Yong Shih Mei   ³ , MBBS ;   Shazana Rifham Abdullah   ³ , MD, MPH, DrPH ;   Norfashihah Faridus   ³ , BSc ;   Nur Azirah Md Yusof   ³ , BSc, MSc ;   Nur Najwa Farahin M Yusoff   ³ , BSc ;   Rahman Jamal   ⁴ , MD, PhD ;   Aizai Azan Abdul Rahim   ⁵ , MD, MMed ;   Abdul Kahar Abdul Ghapar   ⁶ , MD, MMed ;   Ammu Kutty Radhakrishnan   ⁷ , BSc, MSc, PhD ;   Alan Yean Yip Fong   ^{8, 9} , MBChB, MRCP ;   Omar Ismail   ¹⁰ , MD, MMed ;   Saravanan Krishinan   ¹¹ , MBBS, MRCP ;   Chuey Yan Lee   ¹² , MBBS, MRCP ;   Liew Houng Bang   ¹³ , BAO, MBBCH, MRCP ;   Eashwary Mageswaren   ¹⁴ , MBBS, MMed ;   Kauthaman Mahendran   ¹⁵ , MBBS, MRCP ;   Nor Hanim Mohd Amin   ¹⁶ , MD, MMed ;   Gunavathy Muthusamy   ¹⁷ , MD, MMed ;   Aaron Ong Hean Jin   ¹⁸ , MBBS, MRCP ;   Ahmad Wazi Ramli   ¹⁹ , MD, MMed ;   Noel Thomas Ross   ²⁰ , MBBS, MMed ;   Anwar Irawan Ruhani   ²¹ , MBBS, MMed ;   Mansor Yahya   ³ , MD, MMed ;   Yusniza Yusoff   ²² , MD, MMed ;   Siti Khairani Zainal Abidin   ¹⁴ , MD, MMed ;   Laryssa Amado   ¹ , IR, MSc ;   Thomas Bolton   ^{1, 23} , BSc, MAst, MSc, PhD ;   Sophie Weston   ¹ , BA, MSc ;   Jason Crawte   ¹ , BTEC ;   Niko Ovenden   ¹ , MA, MSc ;   Ank Michielsen   ¹ , BSc, MBA, MSc ;   Md Mostafa Monower   ²⁴ , MD ;   Wan Rozita Wan Mahiyuddin   ³ , BSc, MSc, PhD ;   Angela Wood   ^{1, 23, 25, 26} , BSc, PhD ;   Emanuele Di Angelantonio   ^{1, 23, 25, 26} , MD, MSc, PhD ;   Nur Suffia Sulaiman   ³ , MBChB, MPH, DrPH ;   John Danesh   ^{1, 23, 25, 26, 27} , MD, MSc, DPhil ;   Adam S Butterworth   ^{1, 23, 25, 26} , BA, MSc, PhD

¹ British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom

² Centre for Non-Communicable Disease Research, Dhaka, Bangladesh

³ Institute for Medical Research, National Institute of Health, Ministry of Health, Kuala Lumpur, Malaysia

⁴ UKM Medical Molecular Biological Institute, Kuala Lumpur, Malaysia

⁵ National Heart Institute, Kuala Lumpur, Malaysia

⁶ Department of Cardiology, Hospital Serdang, Selangor, Malaysia

⁷ Jeffery Cheah School of Medicine and Health Sciences, Monash University Malaysia, Subang Jaya, Malaysia

⁸ Department of Cardiology, Sarawak Heart Centre, Kota Samarahan, Malaysia

⁹ Clinical Research Centre, Institute for Clinical Research, Sarawak General Hospital, Kuching, Malaysia

¹⁰ Department of Cardiology, Hospital Pulau Pinang, Pulau Pinang, Malaysia

¹¹ Department of Cardiology, Hospital Sultanah Bahiyah, Kedah, Malaysia

¹² Department of Cardiology, Hospital Sultanah Aminah, Johor, Malaysia

¹³ Department of Cardiology & Clinical Research Centre, Hospital Queen Elizabeth II, Sabah, Malaysia

¹⁴ Department of General Medicine, Hospital Tengku Ampuan Rahimah, Selangor, Malaysia

¹⁵ Department of General Medicine & Clinical Research Centre, Hospital Melaka, Melaka, Malaysia

¹⁶ Department of General Medicine, Hospital Raja Permaisuri Bainun, Perak, Malaysia

¹⁷ Department of General Medicine, Hospital Shah Alam, Selangor, Malaysia

¹⁸ Department of General Medicine, Hospital Tuanku Fauziah, Perlis, Malaysia

¹⁹ Department of Cardiology, Hospital Sultanah Nur Zahirah, Terengganu, Malaysia

²⁰ Department of General Medicine, Hospital Kuala Lumpur, Kuala Lumpur, Malaysia

²¹ Department of Cardiology, Hospital Tengku Ampuan Afzan, Pahang, Malaysia

²² Department of General Medicine, Hospital Sungai Buloh, Selangor, Malaysia

²³ National Institute for Health Research Blood and Transplant Research Unit in Donor Health and Genomics, University of Cambridge, Cambridge, United Kingdom

²⁴ National Heart Foundation Hospital & Research Institute, Mirpur, Dhaka, Bangladesh

²⁵ Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Cambridge, United Kingdom

²⁶ British Heart Foundation Centre of Research Excellence, University of Cambridge, Cambridge, United Kingdom

²⁷ Department of Human Genetics, Wellcome Sanger Institute, Hinxton, United Kingdom