Evaluation and Management of Dyspnea in Hypermobile Ehlers-Danlos Syndrome and Generalized Hypermobility Spectrum Disorder: Protocol for a Pilot and Feasibility Randomized Controlled Trial

Dmitry Rozenberg   ^{1, 2, 3 *} , MD, PhD ;   Noor Al Kaabi   ^{2, 3, 4 *} , HBSc ;   Encarna Camacho Perez   ^{3, 4} , MSc ;   Sahar Nourouzpour   ⁴ , MSc ;   Laura Lopez-Hernandez   ³ , BSc, PT ;   Laura McGillis   ³ , BNSc, RN ;   Ewan Goligher   ^{2, 4, 5} , MD, PhD ;   W Darlene Reid   ^{6, 7} , PhD ;   Chung-Wai Chow   ^{2, 4} , MD, PhD ;   Clodagh M Ryan   ⁶ , MD ;   Dinesh Kumbhare   ^{2, 6, 8} , MD, PhD ;   Ella Huszti   ⁹ , MSc, PhD ;   Kateri Champagne   ¹⁰ , MSc, MD ;   Satish Raj   ¹¹ , MSc, MD ;   Susanna Mak   ^{2, 12} , MD, PhD ;   Daniel Santa Mina   ^{3, 8, 13} , PhD ;   Hance Clarke   ^{2, 3, 13} , MD, PhD ;   Nimish Mittal   ^{2, 3, 6, 8, 13} , MSc, MD

¹ Respirology and Lung Transplantation, Toronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada

² Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada

³ GoodHope Ehlers-Danlos Syndrome Clinic, University Health Network, Toronto, ON, Canada

⁴ Respirology, Toronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada

⁵ Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, ON, Canada

⁶ KITE—Toronto Rehab, University Health Network, Toronto, ON, Canada

⁷ Physical Therapy, University of Toronto, Toronto, ON, Canada

⁸ Faculty of Kinesiology and Physical Education, University of Toronto, Toronto, ON, Canada

⁹ Biostatistics Research Unit, University Health Network, Toronto, ON, Canada

¹⁰ Institut de Médecine du Sommeil, Montreal, QC, Canada

¹¹ Department of Cardiac Sciences, Cumming School of Medicine, Calgary, AB, Canada

¹² Department of Cardiology, Mount Sinai Hospital, Toronto, ON, Canada

¹³ Department of Anesthesia and Pain Management, University Health Network, Toronto, ON, Canada

*these authors contributed equally