Digital Guardian Angel Supported by an Artificial Intelligence System to Improve Quality of Life, Well-being, and Health Outcomes of Patients With Cancer (ONCORELIEF): Protocol for a Single Arm Prospective Multicenter Pilot Study

Joaquim Reis   ^{1 *} , PhD ;   Luzia Travado   ^{1 *} , PhD ;   Alexander Scherrer   ^{2 *} , PhD ;   Thanos Kosmidis   ^{3 *} , MSc ;   Stefanos Venios   ^{4 *} , MSc ;   Paris Emmanouil Laras   ^{5 *} , BA ;   Gabrielle Oestreicher   ^{6 *} , MSc ;   Markus Moehler   ^{6 *} , MD ;   Margherita Parolini   ^{7 *} , MD ;   Alessandro Passardi   ^{7 *} , MD ;   Elena Meggiolaro   ^{7 *} , MSc ;   Giovanni Martinelli   ^{7 *} , MD ;   Elisabetta Petracci   ^{7 *} , PhD ;   Chiara Zingaretti   ⁷ , MSc ;   Sotiris Diamantopoulos   ⁸ , PhD ;   Maria Plakia   ^{8 *} , MSc ;   Charalampos Vassiliou   ^{9 *} , MSc ;   Suheib Mousa   ^{10 *} , MSc ;   Robert Zifrid   ^{10 *} , MSc ;   Francesco Giulio Sullo   ^{7 *} , MD ;   Chiara Gallio   ^{7 *} , MD

¹ Institute of Biophysics and Biomedical Engineering, Faculty of Sciences, University of Lisbon, Lisboa, Portugal

² Institute for Industrial Mathematics, Fraunhofer-Institut für Techno- und Wirtschaftsmathematik (ITWM), Kaiserslautern, Germany

³ Careacross, London, United Kingdom

⁴ Suite5, Data Intelligence Solutions Limited, Limassol, Cyprus

⁵ Maggioli SPA, Santarcangelo di Romagna, Italy

⁶ Universitaetsmedizin der Johannes Gutenberg-Universitaet Mainz, Mainz, Germany

⁷ IRCCS Istituto Romagnolo per lo Studio dei Tumori “Dino Amadori”, IRST S.r.L., Meldola, Italy

⁸ Exus Software, London, United Kingdom

⁹ Innosystems, Athens, Greece

¹⁰ MCS Datalabs, Berlin, Germany

*these authors contributed equally