Creating an Innovative Artificial Intelligence–Based Technology (TCRact) for Designing and Optimizing T Cell Receptors for Use in Cancer Immunotherapies: Protocol for an Observational Trial

Joanna Bujak   ^{1, 2 *} , PhD ;   Stanisław Kłęk   ^{3 *} , MD, PhD ;   Martyna Balawejder   ¹ , MSc ;   Aleksandra Kociniak   ¹ , MSc ;   Kinga Wilkus   ¹ , MSc ;   Rafał Szatanek   ¹ , PhD ;   Zofia Orzeszko   ⁴ , MD ;   Joanna Welanyk   ³ , MD ;   Grzegorz Torbicz   ⁵ , MD ;   Mateusz Jęckowski   ⁶ , MD ;   Tomasz Kucharczyk   ⁷ , MD ;   Łukasz Wohadlo   ⁸ , MD, PhD ;   Maciej Borys   ⁵ , MD ;   Honorata Stadnik   ⁹ , MD, PhD ;   Michał Wysocki   ⁵ , MD, PhD ;   Magdalena Kayser   ¹⁰ , MD ;   Marta Ewa Słomka   ⁶ , MD, PhD ;   Anna Kosmowska   ¹⁰ , MD ;   Karolina Horbacka   ¹⁰ , MD, PhD ;   Tomasz Gach   ¹¹ , MD, PhD ;   Beata Markowska   ¹¹ , MD ;   Tomasz Kowalczyk   ⁸ , MD, PhD ;   Jacek Karoń   ¹⁰ , MD, PhD ;   Marek Karczewski   ⁹ , MD, PhD ;   Mirosław Szura   ¹¹ , MD, PhD ;   Anna Sanecka-Duin   ^{1 *} , PhD ;   Agnieszka Blum   ^{1 *} , MD, PhD

¹ Ardigen SA, Cracow, Poland

² Department of Physics and Biophysics, Institute of Biology, Warsaw University of Life Sciences, Warszawa, Poland

³ Surgical Oncology Clinic, Maria Sklodowska-Curie National Research Institute of Oncology, Cracow, Poland

⁴ Department of General and Oncological Surgery, Brothers Hospitallers Hospital, Cracow, Poland

⁵ Department of General Surgery and Surgical Oncology, Ludwik Rydygier Memorial Hospital, Cracow, Poland

⁶ Colon Cancer Unit, Department of Oncological Surgery, Voivodeship Multi-Specialist Center for Oncology and Traumatology, Lodz, Poland

⁷ Holy Cross Cancer Center Clinic of Clinical Oncology, Cracow, Poland

⁸ Department of General Surgery, Andrzej Frycz Modrzewski Krakow University, Cracow, Poland

⁹ Department of General and Transplant Surgery, Poznan University of Medical Sciences, University Hospital, Poznan, Poland

¹⁰ General and Colorectal Surgery Department, J Struś Multispecialist Municipal Hospital, Poznan, Poland

¹¹ Surgical Clinic Institute of Physiotherapy, Faculty of Health Sciences, Jagiellonian University Medical College, Cracow, Poland

*these authors contributed equally