An eHealth App (CAPABLE) Providing Symptom Monitoring, Well-Being Interventions, and Educational Material for Patients With Melanoma Treated With Immune Checkpoint Inhibitors: Protocol for an Exploratory Intervention Trial

Itske Fraterman   ¹ , MSc ;   Barbara M Wollersheim   ¹ , PhD ;   Valentina Tibollo   ² , MSc ;   Savannah Lucia Catherina Glaser   ^{3, 4} , MSc ;   Stephanie Medlock   ^{3, 4, 5} , DVM, PhD ;   Ronald Cornet   ^{3, 4} , PhD ;   Matteo Gabetta   ^{6, 7} , PhD ;   Vitali Gisko   ⁸ , BA ;   Ella Barkan   ⁹ , MA ;   Nicola di Flora   ¹⁰ , BBA ;   David Glasspool   ¹¹ , PhD ;   Alexandra Kogan   ¹² , MSc ;   Giordano Lanzola   ⁷ , PhD ;   Roy Leizer   ¹² , MSc ;   Henk Mallo   ¹³ , MSc ;   Manuel Ottaviano   ¹⁴ , PhD ;   Mor Peleg   ¹² , PhD ;   Lonneke V van de Poll-Franse   ^{1, 15, 16} , PhD ;   Nicole Veggiotti   ⁷ , MSc ;   Konrad Śniatała   ¹⁷ , MSc ;   Szymon Wilk   ¹⁷ , PhD ;   Enea Parimbelli   ⁷ , PhD ;   Silvana Quaglini   ⁷ , PhD ;   Mimma Rizzo   ¹⁸ , MD ;   Laura Deborah Locati   ^{19, 20} , MD ;   Annelies Boekhout   ¹ , PhD ;   Lucia Sacchi   ⁷ , PhD ;   Sofie Wilgenhof   ¹³ , MD, PhD

¹ Department of Psychosocial Research and Epidemiology, The Netherlands Cancer Institute, Amsterdam, Netherlands

² Laboratory of Informatics and Systems Engineering for Clinical Research, Istituti Clinici Scientifici Maugeri SpA SB IRCCS, Pavia, Italy

³ Medical Informatics, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands

⁴ Methodology, Amsterdam Public Health Research Institute, Amsterdam, Netherlands

⁵ Aging and Later Life, Amsterdam Public Health Research Institute, Amsterdam, Netherlands

⁶ BIOMERIS SRL, Pavia, Italy

⁷ Department of Electrical, Computer and Biomedical Engineering, University of Pavia, Pavia, Italy

⁸ BITSENS JSC, Vilnius, Lithuania

⁹ Department of Artificial Intelligence for Accelerated Healthcare and Life Sciences Discovery, IBM Research, IBM R&D Laboratories, Haifa, Israel

¹⁰ Associazione Italiana Malati di Cancro, Rome, Italy

¹¹ Deontics Ltd, London, United Kingdom

¹² Department of Information Systems, University of Haifa, Haifa, Israel

¹³ Department of Medical Oncology, Netherlands Cancer Institute–Antoni van Leeuwenhoek, Amsterdam, Netherlands

¹⁴ Life Supporting Technologies, Universidad Politécnica de Madrid, Madrid, Spain

¹⁵ Department of Research and Development, Netherlands Comprehensive Cancer Organization, Utrecht, Netherlands

¹⁶ Department of Medical and Clinical Psychology, Center of Research on Psychological and Somatic Disorders (CoRPS), Tilburg University, Tilburg, Netherlands

¹⁷ Institute of Computing Science, Poznan University of Technology, Poznan, Poland

¹⁸ Division of Medical Oncology, Azienda Ospedaliero Universitaria Consorziale Policlinico di Bari, Bari, Italy

¹⁹ Department of Internal Medicine and Medical Therapy, University of Pavia, Pavia, Italy

²⁰ Medical Oncology Unit, Istituti Clinici Scientifici Maugeri IRCCS, Pavia, Italy