Assessment of the Feasibility of Objective Parameters as Primary End Points for Patients Affected by Knee Osteoarthritis: Protocol for a Pilot, Open Noncontrolled Trial (:SMILE:)

Dumitru Emanuel Dogaru   ^{1 *} , MSc ;   Serban Rosu   ^{2 *} , MD, PhD, Dr med ;   Dionisio Franco Barattini   ^{3 *} , MBA, MSc, MD ;   Simone Guadagna   ^{3 *} , PhD ;   Luca Barattini   ^{4 *} , MSc ;   Bogdan Andor   ^{1, 5 *} , MD, PhD

¹ Department of Orthopaedics - Traumatology, Victor Babeş University of Medicine and Pharmacy, Timisoara, Romania

² Clinical Research, Oral and Maxillofacial Surgery, Victor Babeş University of Medicine and Pharmacy, Timisoara, Romania

³ Opera CRO, a TIGERMED company, Timisoara, Romania

⁴ TIGERMED Italy, Genova, Italy

⁵ Profesor Universitar Doctor Teodor Șora Research Centre, Victor Babeş University of Medicine and Pharmacy, Timisoara, Romania

*all authors contributed equally