Integration of Digital Phenotyping and Genomics for Dry Eye Disease: Protocol for a Prospective Cohort Study

Ken Nagino   ^{1, 2, 3, 4 *} , PhD ;   Yasutsugu Akasaki   ^{1, 2 *} , MD, PhD ;   Nobuo Fuse   ^{5, 6} , MD, PhD ;   Soichi Ogishima   ^{5, 6} , PhD ;   Atsushi Shimizu   ^{7, 8} , PhD ;   Akira Uruno   ⁵ , MD, PhD ;   Yoichi Sutoh   ^{7, 9} , PhD ;   Yayoi Otsuka-Yamasaki   ^{7, 9} , PhD ;   Fuji Nagami   ^{5, 6} , PhD ;   Jun Seita   ⁸ , MD, PhD ;   Tomohiro Nakamura   ^{5, 10} , PhD ;   Satoshi Nagaie   ⁵ , PhD ;   Makiko Taira   ^{5, 11, 12} , MD, PhD ;   Tomoko Kobayashi   ⁵ , MD, PhD ;   Ritsuko Shimizu   ^{5, 6} , MD, PhD ;   Atsushi Hozawa   ⁵ , MD, PhD ;   Shinichi Kuriyama   ^{5, 6} , MD, PhD ;   Atsuko Eguchi   ³ , PhD ;   Akie Midorikawa-Inomata   ^{3, 4} , MPH, PhD ;   Masahiro Nakamura   ¹ , MD, PhD ;   Akira Murakami   ¹ , MD, PhD ;   Shintaro Nakao   ¹ , MD, PhD ;   Takenori Inomata   ^{1, 2, 3, 4, 13} , MD, MBA, PhD

¹ Department of Ophthalmology, Juntendo University Graduate School of Medicine, Tokyo, Japan

² Department of Digital Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan

³ Department of Hospital Administration, Juntendo University Graduate School of Medicine, Tokyo, Japan

⁴ Department of Telemedicine and Mobile health, Juntendo University Graduate School of Medicine, Tokyo, Japan

⁵ Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan

⁶ Advanced Research Center for Innovations in Next-Generation Medicine, Tohoku University, Sendai, Japan

⁷ Division of Biomedical Information Analysis, Iwate Tohoku Medical Megabank Organization, Disaster Reconstruction Center, Iwate Medical University, Yahaba, Japan

⁸ Advanced Data Science Project, RIKEN Information R&D and Strategy Headquarters, RIKEN, Tokyo, Japan

⁹ Division of Biomedical Information Analysis, Institute for Biomedical Sciences, Iwate Medical University, Yahaba, Japan

¹⁰ Department of Data Science, Kyoto Women's University, Kyoto, Japan

¹¹ Department of Neurology, Neuroscience & Sensory Organs, Tohoku University Graduate of Medicine, Sendai, Japan

¹² Department of Neurology, Tohoku University Hospital, Sendai, Japan

¹³ Data Science, Juntendo University Graduate School of Medicine, Tokyo, Japan

*these authors contributed equally