The Effects of a Modified Mediterranean Diet on Gut Microbiota and Chemotherapy Side Effects in Patients With Metastatic Colorectal Cancer Undergoing First-Line Chemotherapy With or Without Either Antiepidermal Growth Factor Receptor or Antivascular Endothelial Growth Factor Agent: Protocol for a Randomized Pilot Study in Italy

Salvatore Artale   ¹ , MD ;   Francesca Filiali   ¹ , MD ;   Elena Beretta   ² , MD ;   Francesca Arosio   ¹ , BD ;   Federica Cazzaniga   ¹ , BD ;   Carlo Tersalvi   ³ , MD ;   Michele Sofia   ⁴ , MD ;   Paola Tagliabue   ¹ , MD ;   Paola Pozzi   ² , MD ;   Andrea Colombo   ¹ , MD ;   Claudia Carbone   ¹ , MD ;   Lisa Pietrogiovanna   ¹ , MD ;   Magda Verga   ¹ , MD ;   Paola Nova   ¹ , MD ;   Rossella Calori   ¹ , MD ;   Rossella Renso   ¹ , MD ;   Selene Rota   ¹ , MD ;   Stefania Aglione   ¹ , MD ;   Italo Manfrida   ² , MD ;   Giovanna Facendola   ² , MD ;   Alessandra Trojani   ⁵ , PhD ;   Maria Chiara Dazzani   ¹ , MD ;   Sabrina Basciani   ⁶ , PhD ;   Maria Grazia Valsecchi   ⁷ , PhD ;   Giulia Capitoli   ⁷ , PhD ;   Cinzia Cocola   ⁸ , PhD ;   Clarissa Consolandi   ⁸ , PhD

¹ Oncology Unit, Azienda Socio-Sanitaria Territoriale della Brianza, Vimercate Hospital, Vimercate, Italy

² Oncology Unit, Azienda Socio-Sanitaria Territoriale della Brianza, Desio Hospital, Desio, Italy

³ General Management, Azienda Socio-Sanitaria Territoriale della Brianza, Vimercate Hospital, Vimercate, Italy

⁴ Health Management Department, Azienda Socio-Sanitaria Territoriale della Brianza, Vimercate Hospital, Vimercate, Italy

⁵ Department of Hematology and Oncology, Azienda Socio-Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda, Milan, Italy

⁶ Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy

⁷ School of Medicine and Surgery, Center of Bioinformatics, Biostatistics and Bioimaging, University of Milano-Bicocca, Monza, Italy

⁸ Institute of Biomedical Technologies, National Research Council, Segrate, Italy