RCTs - Protocols/Proposals (funded, already peer-reviewed, non-eHealth)

A Randomized Controlled Trial Investigating the Feasibility of a Low-Intensity Psychological Intervention for Fear of Memory Loss and Quality of Life in Older Adults: Protocol for the Reducing Fear and Avoidance of Memory Loss (REFRAME) Study

Patricia O'Loughlin, Pavithra Pavithra, John Regan, Marc Bennett, Rachel Knight, Bert Lenaert, Melissa Marquez, Michelle Taddeo, James Griffith, Rita Shapiro, Francesca Farina

JMIR Res Protoc 2021 (Jul 30); 10(7):e30514

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Combining Ketamine and Internet-Based Cognitive Behavioral Therapy for the Treatment of Posttraumatic Stress Disorder: Protocol for a Randomized Controlled Trial

Aaron Emile Philipp-Muller, Taras Reshetukha, Gustavo Vazquez, Roumen Milev, Dawn Armstrong, Jasleen Jagayat, Nazanin Alavi

JMIR Res Protoc 2021 (Jul 20); 10(7):e30334

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Presence of Urinary Exosomes for Liquid Biopsy of Clear Cell Renal Cell Carcinoma: Protocol for a Pilot Feasibility Study

Guorong Li, Nora Mallouk, Pascale Flandrin, Arnauld Garcin, Claude Lambert, Sid Ali Berremila, Hocine Habchi, Nicolas Mottet

JMIR Res Protoc 2021 (Jul 20); 10(7):e24423

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Optimizing Oral Targeted Anticancer Therapies Study for Patients With Solid Cancer: Protocol for a Randomized Controlled Medication Adherence Program Along With Systematic Collection and Modeling of Pharmacokinetic and Pharmacodynamic Data

Carole Bandiera, Evelina Cardoso, Isabella Locatelli, Antonia Digklia, Khalil Zaman, Antonella Diciolla, Valérie Cristina, Athina Stravodimou, Aedo Lopez Veronica, Ana Dolcan, Apostolos Sarivalasis, Aikaterini Liapi, Hasna Bouchaab, Angela Orcurto, Jennifer Dotta-Celio, Solange Peters, Laurent Decosterd, Nicolas Widmer, Dorothea Wagner, Chantal Csajka, Marie Paule Schneider

JMIR Res Protoc 2021 (Jun 29); 10(6):e30090

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Physical Activity Together for People With Multiple Sclerosis and Their Care Partners: Protocol for a Feasibility Randomized Controlled Trial of a Dyadic Intervention

Afolasade Fakolade, Julie Cameron, Odessa McKenna, Marcia L Finlayson, Mark S Freedman, Amy E Latimer-Cheung, Lara A Pilutti

JMIR Res Protoc 2021 (Jun 01); 10(6):e18410

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Treatment of Barth Syndrome by Cardiolipin Manipulation (CARDIOMAN) With Bezafibrate: Protocol for a Randomized Placebo-Controlled Pilot Trial Conducted in the Nationally Commissioned Barth Syndrome Service

Lucy Dabner, Guido E Pieles, Colin G Steward, Julian P Hamilton-Shield, Andrew R Ness, Chris A Rogers, Chiara Bucciarelli-Ducci, Rosemary Greenwood, Lucy Ellis, Karen Sheehan, Barnaby C Reeves

JMIR Res Protoc 2021 (May 31); 10(5):e22533

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Engaging Caregivers and Providers of Children With Sickle Cell Anemia in Shared Decision Making for Hydroxyurea: Protocol for a Multicenter Randomized Controlled Trial

Anna M Hood, Heather Strong, Cara Nwankwo, Yolanda Johnson, James Peugh, Constance A Mara, Lisa M Shook, William B Brinkman, Francis J Real, Melissa D Klein, Rogelle Hackworth, Sherif M Badawy, Alexis A Thompson, Jean L Raphael, Amber M Yates, Kim Smith-Whitley, Allison A King, Cecelia Calhoun, Susan E Creary, Connie M Piccone, Aimee K Hildenbrand, Steven K Reader, Lynne Neumayr, Emily R Meier, Amy E Sobota, Sohail Rana, Maria Britto, Kay L Saving, Marsha Treadwell, Charles T Quinn, Russell E Ware, Lori E Crosby

JMIR Res Protoc 2021 (May 21); 10(5):e27650

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Interrupting Sitting Time in Postmenopausal Women: Protocol for the Rise for Health Randomized Controlled Trial

Sheri J Hartman, Lindsay W Dillon, Andrea Z LaCroix, Loki Natarajan, Dorothy D Sears, Neville Owen, David W Dunstan, James F Sallis, Simon Schenk, Matthew Allison, Michelle Takemoto, Alexandra M Herweck, Bao Nguyen, Dori E Rosenberg

JMIR Res Protoc 2021 (May 13); 10(5):e28684

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Effectiveness of an Integrated Care Package for Refugee Mothers and Children: Protocol for a Cluster Randomized Controlled Trial

Zunayed Al Azdi, Khaleda Islam, Muhammad Amir Khan, Nida Khan, Amna Ejaz, Muhammad Ahmar Khan, Azza Warraitch, Ishrat Jahan, Rumana Huque

JMIR Res Protoc 2021 (May 04); 10(5):e25047

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Uncovering the Bone-Muscle Interaction and Its Implications for the Health and Function of Older Adults (the Wellderly Project): Protocol for a Randomized Controlled Crossover Trial

Cassandra Smith, Xuzhu Lin, David Scott, Tara C Brennan-Speranza, Ahmed Al Saedi, Alba Moreno-Asso, Mary Woessner, Ebrahim Bani Hassan, Nir Eynon, Gustavo Duque, Itamar Levinger

JMIR Res Protoc 2021 (Apr 09); 10(4):e18777

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Effect of Reading Rehabilitation for Age-Related Macular Degeneration on Cognitive Functioning: Protocol for a Nonrandomized Pre-Post Intervention Study

Walter Wittich, M Kathleen Pichora-Fuller, Aaron Johnson, Sven Joubert, Eva Kehayia, Vanessa Bachir, Gabrielle Aubin, Atul Jaiswal, Natalie Phillips

JMIR Res Protoc 2021 (Mar 11); 10(3):e19931

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The Impact of Nonpharmacological Interventions on Patient Experience, Opioid Use, and Health Care Utilization in Adult Cardiac Surgery Patients: Protocol for a Mixed Methods Study

Alexander A Brescia, Julie R Piazza, Jessica N Jenkins, Lindsay K Heering, Alexander J Ivacko, James C Piazza, Molly C Dwyer-White, Stefanie L Peters, Jesus Cepero, Bailey H Brown, Faraz N Longi, Katelyn P Monaghan, Frederick W Bauer, Varun G Kathawate, Sara M Jafri, Melissa C Webster, Amanda M Kasperek, Nickole L Garvey, Claudia Schwenzer, Xiaoting Wu, Kiran H Lagisetty, Nicholas H Osborne, Jennifer F Waljee, Michelle Riba, Donald S Likosky, Mary E Byrnes, G Michael Deeb

JMIR Res Protoc 2021 (Feb 16); 10(2):e21350

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Program for Healthier School Cafeterias in Rio Grande do Sul, Brazil: Protocol for a Community-Based Randomized Trial

Mariana Balestrin, Carla Cristina Bauermann Brasil, Ericles Andrei Bellei, Vanessa Ramos Kirsten, Mario Bernardes Wagner

JMIR Res Protoc 2021 (Jan 19); 10(1):e22680

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Repeated Transcranial Magnetic Stimulation for Improving Cognition in Patients With Alzheimer Disease: Protocol for a Randomized, Double-Blind, Placebo-Controlled Trial

Zahra Moussavi, Grant Rutherford, Brian Lithgow, Colleen Millikin, Mandana Modirrousta, Behzad Mansouri, Xikui Wang, Craig Omelan, Lesley Fellows, Paul Fitzgerald, Lisa Koski

JMIR Res Protoc 2021 (Jan 08); 10(1):e25144

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Effects of Unfiltered Cigarettes on Smoking Behavior and Toxicant Exposure: Protocol for a Randomized Crossover Clinical Trial

Eyal Oren, Kim Pulvers, Devan R Romero, Casey Barber, Erika Carter, Laree A Tracy, Thomas E Novotny

JMIR Res Protoc 2020 (Dec 08); 9(12):e19603

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Long-Term Follow-Up of a Randomized Controlled Trial to Reduce Excessive Weight Gain in Infancy: Protocol for the Prevention of Overweight in Infancy (POI) Follow-Up Study at 11 Years

Taiwo O Adebowale, Barry J Taylor, Andrew R Gray, Barbara C Galland, Anne-Louise M Heath, Sarah Fortune, Kim A Meredith-Jones, Trudy Sullivan, Deborah McIntosh, Bradley Brosnan, Rachael W Taylor

JMIR Res Protoc 2020 (Nov 30); 9(11):e24968

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The Precision Health and Everyday Democracy (PHED) Project: Protocol for a Transdisciplinary Collaboration on Health Equity and the Role of Health in Society

Michael Strange, Carol Nilsson, Slobodan Zdravkovic, Elisabeth Mangrio

JMIR Res Protoc 2020 (Nov 30); 9(11):e17324

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The Role of Demoralization and Meaning in Life (DEMIL) in Influencing Suicidal Ideation Among Patients Affected by Chronic Pain: Protocol of a Single-Center, Observational, Case-Control Study

Alessandra Costanza, Vasileios Chytas, Viridiana Mazzola, Valérie Piguet, Jules Desmeules, Guido Bondolfi, Christine Cedraschi

JMIR Res Protoc 2020 (Nov 26); 9(11):e24882

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Development of a Personalized Mobile Mental Health Intervention for Workplace Cyberbullying Among Health Practitioners: Protocol for a Mixed Methods Study

Yun Jin Kim, Linchao Qian, Muhammad Shahzad Aslam

JMIR Res Protoc 2020 (Nov 20); 9(11):e23112

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Effect of Pain Education and Exercise on Pain and Function in Chronic Achilles Tendinopathy: Protocol for a Double-Blind, Placebo-Controlled Randomized Trial

Andrew A Post, Ebonie K Rio, Kathleen A Sluka, G Lorimer Moseley, Emine O Bayman, Mederic M Hall, Cesar de Cesar Netto, Jason M Wilken, Jessica F Danielson, Ruth Chimenti

JMIR Res Protoc 2020 (Nov 03); 9(11):e19111

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