RCTs - Protocols/Proposals (eHealth)

Articles published in 2026 in this theme: 40 (scroll down to load remaining articles)

2026

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Effectiveness and Feasibility of Self-Monitoring for Weight Management in Individuals With Mental Disorders Using Digital Intervention: Protocol for a Stepped-Wedge Cluster Randomized Trial (“SWIM” Study)

Jiamiao Wu, Jinjie Xu, Jingyi Bi, Xuequan Zhu, Le Xiao

JMIR Res Protoc 2026 (Apr 27); 15:e78420

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Social Media–Based Professional Intervention vs Resource Provision for Youth With Suicidal Ideation or Behavior: Protocol for a Randomized Controlled Trial

Margot Morgiève, Leloup Manon, Anne-Christine Lesniak, Laurine Rougegrez, Nathalie Rigbourg, Vincent Jardon, Marielle Wathelet, Anne-Laure Demarty, Karim Dahache, Alain Duhamel, Thomas Delbarre, Pierre Grandgenèvre, Charles-Edouard Notredame

JMIR Res Protoc 2026 (Apr 24); 15:e83303

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The Effect of an Educational Intervention on the Knowledge and Self-Care Skills of Adult Patients With Venous Leg Ulcers: Protocol for a Randomized Controlled Trial

Cristina Canova, Jessica Scappin, Maria Vittoria Chiaruttini, Laura Tasson, Flavia Masiero, Claudia Varagnolo, Matteo Martinato

JMIR Res Protoc 2026 (Apr 21); 15:e84211

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Overcoming the HIV Pre-Exposure Prophylaxis Uptake Barrier With A Health Action Process Approach and Conditional Economic Incentives Among Men Who Have Sex With Men in 3 Chinese Cities: Protocol for a Randomized Controlled Trial

Hao Lin, Mojun Ni, Chun Chang, Feng Sun, Jinghua Li, Omar Galárraga, Phoenix Kit-Han Mo, Wangnan Cao

JMIR Res Protoc 2026 (Apr 20); 15:e82123

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Implementation of a Cancer Navigation Intervention for Newly Diagnosed Survivors of Breast Cancer: Protocol for a Randomized Controlled Trial

Melba Sheila D'Souza, Ruby Gidda, Michelle Smith, Arati Swaminadhan, Amy Jean Strank, Ashwin Nairy

JMIR Res Protoc 2026 (Apr 20); 15:e85820

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Combining Digital Cognitive Behavioral Therapy With Mindfulness Training for Binge Eating Disorder: Protocol for a Feasibility Trial

Margaret Sala, Corey Roos, Dante Ascarrunz, Casey M Stern, Jonathan Bricker, Jonathan M Feldman, Cheri Levinson, Mihaela Aslan, Jennifer L Hay, Hedy Kober

JMIR Res Protoc 2026 (Apr 17); 15:e91761

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Feasibility of Internet-Based Mind-Body Training for Adults With Subjective Cognitive Decline: Protocol for a Randomized Controlled Trial

Ruchika S Prakash, Madhura Phansikar, Megan E Fisher, Sarah Dove, Rebecca Andridge, Doug Scharre, Kathy D Wright, Elizabeth Head, Claire O'Callaghan, Quinn K Meyerson, Elizabeth J Duraney, Matthew Schroeder, Niyathi Chakrapani, Elise K Grant, Tyreek Jones, James Teng, Michael Esterman, Joshua M Smyth, Thomas Gregoire, Rond Malhas

JMIR Res Protoc 2026 (Apr 13); 15:e86276

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A Mobile Self-Assessment and Referral Platform for Family Caregivers of Individuals With Alzheimer Disease and Related Dementias: Protocol for a Pilot Randomized Controlled Trial

Francesca Falzarano, Annabelle Greenfield, Hannah Mason, Katerina Bumbalova, Elizabeth Rojas, Aleksandar Bumbalov

JMIR Res Protoc 2026 (Apr 01); 15:e90244

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Clinical Evaluation of Pediatric Pulse Oximeters in South Africa: Protocol for a Cluster Randomized Controlled Trial

Holly B Schuh, Marieke Van der Zalm, Margaret Van Niekerk, Lise-Marie Laubscher, Abenathi Mcinziba, Steve Gomas, Sunaina Kapoor, Shubhada Hooli, Lario Viljoen, Andre Gie, Bareng A S Nonyane, Pierre Goussard, Anneke C Hesseling, Carina King, Eric D McCollum

JMIR Res Protoc 2026 (Mar 30); 15:e82888

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Development of a Collaborative Education Program for Home Care Nursing Educators’ on-the-Job Training in End-of-Life Home Care: Protocol for a Randomized Controlled Trial

Ryousuke Yamada, Hanako Numata, Yuka Sumikawa, Kosuke Kashiwabara, Maiko Noguchi-Watanabe, Kayoko Kurita, Noriko Yamamoto-Mitani

JMIR Res Protoc 2026 (Mar 27); 15:e84330

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Impact Assessment of the Allergy Fact Checker, a Clinical Decision Support Tool for Noninvasive Beta-Lactam Antibiotic Allergy Label Delabeling: Protocol for a Multicenter Crossover Cluster-Controlled Study

Liesbeth Gilissen, Greet Van De Sijpe, Isabel Spriet, Rik Schrijvers

JMIR Res Protoc 2026 (Mar 27); 15:e86056

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Assessing the Implementation and Potential Effects of the Nishauri mHealth Intervention on HIV Care Among Men in Homa Bay County, Kenya: Protocol for a Mixed Methods Study

Dan Omollo, Pamela Murnane, Louisa Ndunyu, Dallas Swendeman, Sheri D Weiser, Collins Ouma

JMIR Res Protoc 2026 (Mar 24); 15:e85279

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The TBI-AD/ADRD Caregiver Support Intervention (TACSI): Protocol of a Pilot Randomized Controlled Trial Evaluation of a Remote Intervention for Family Caregivers

Samantha Ostenso, Robyn W Birkeland, Elizabeth Albers, Katie W Louwagie, Allison Iwan, Sherry S Chesak, Joseph E Gaugler

JMIR Res Protoc 2026 (Mar 17); 15:e81125

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Evaluation of the Positive Peers Mobile App for Supporting the Viral Suppression of Young People With HIV: Protocol for a Concurrent Mixed Methods Evaluation With Randomized Controlled Clinical Trial and Observational Cohort

Mary M Step, L Anthony Catania, Jennifer McMillen Smith, Steven A Lewis, Yanis Bitar, Vinay K Cheruvu, Kristen A Berg, Jeffrey S Hallam, Ann K Avery

JMIR Res Protoc 2026 (Mar 17); 15:e87601

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Effects of 5-Minute Light-Intensity Physical Activity Breaks (Sit-Cycling and Stand-Twisting) on Cognitive Function, Sleepiness, and Back Pain in Physically Inactive University Students: Protocol for a Mixed-Design Laboratory Study

Jiameng Ma, Buan Kiong Terence Chua, You Hui Jacqueline Chin, Wei Peng Teo, Hyunshik Kim, Seow Ting Low, Dan Li, Yong Hwa Michael Chia

JMIR Res Protoc 2026 (Mar 17); 15:e82510

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Impact of the Population Medicine Multimorbidity Intervention in Xishui County (POPMIX) on People at High Risk for Chronic Obstructive Pulmonary Disease Who Experience Mental Health Symptoms: Protocol for the POPMIX-MH Cluster Randomized Controlled Trial

Yuhao Liu, Wenjin Chen, Shiyu Zhang, Yingping Wang, Zhoutao Zheng, Ke Huang, Xingyao Tang, Zhong Cao, Xunliang Tong, Lei Tang, Jinghan Zhao, Liu He, Lirui Jiao, Tianying Zhao, Yingchi Luo, Qiande Lai, Xiangqin Lyu, Qiushi Chen, Aditi Bunker, Sebastian Vollmer, Pascal Geldsetzer, Dean Jamison, Till Bärnighausen, Ting Yang, Simiao Chen, Chen Wang, POPMIX Group

JMIR Res Protoc 2026 (Mar 06); 15:e85853

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Evaluation of a Community-Based AI-Assisted Visual Impairment Screening Model for Performance, Operational Efficiency, Acceptability, Feasibility, and Costs: Protocol for a 2-Arm Pragmatic Randomized Controlled Trial

Yibing Chen, Kai Hui Koh, Jin Wei Clarine Ho, Samantha Min Er Yew, Jocelyn Hui Lin Goh, Elaine Lum, Yih Chung Tham

JMIR Res Protoc 2026 (Mar 02); 15:e74164

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Preventing and Treating Insomnia Symptoms in Midlife and Older Adults (ASLEEP): Protocol for a Randomized Controlled Trial Using the PROTECT Norge Infrastructure

Jon Arild Aakre, Bjørn Bjorvatn, Martha Therese Gjestsen, Ingvild Dalen, Clive Ballard, Ingelin Testad

JMIR Res Protoc 2026 (Mar 02); 15:e81542

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Comparative Evaluation of AmnioGuard and Advanced Platelet-Rich Fibrin When Combined With NovaBone Putty in the Regeneration of Human Periodontal Infrabony Defects: Protocol for a Randomized Controlled Clinical Trial

Geeta Bhandari, Priyanka Jaiswal, Shweta Bhagat, Sakshi Kotecha

JMIR Res Protoc 2026 (Feb 26); 15:e75987

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PATH Trial for Examining Yoga as a Strategy to Improve Remote-Based Weight Loss in Adults: Protocol for a Randomized Controlled Trial

Selene Y Tobin, Sally Sherman, Beth Bock, Shira Dunsiger, J Graham Thomas, Stephanie P Goldstein, Jessica Unick

JMIR Res Protoc 2026 (Feb 25); 15:e78973

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