Protocol for Combined Analysis of FOXFIRE, SIRFLOX, and FOXFIRE-Global Randomized Phase III Trials of Chemotherapy +/- Selective Internal Radiation Therapy as First-Line Treatment for Patients With Metastatic Colorectal Cancer

Pradeep S Virdee   ¹ , BSc, MSc ;   Joanna Moschandreas   ¹ , BSc, MSc, PhD ;   Val Gebski   ² , MStat ;   Sharon B Love   ¹ , BSc ;   E Anne Francis   ³ , BSc, D. Phil ;   Harpreet S Wasan   ⁴ , MBBS, FRCP ;   Guy van Hazel   ⁵ , MBBS, FRACP, FRCP ;   Peter Gibbs   ⁶ , MBBS, FRACP, MD ;   Ricky A Sharma   ^{7, 8} , MD, PhD

¹ Centre for Statistics in Medicine, University of Oxford, Oxford, United Kingdom

² NHMRC Clinical Trials Centre, University of Sydney, Sydney, Australia

³ Oncology Clinical Trials Office, Department of Oncology, University of Oxford, Oxford, United Kingdom

⁴ Imperial College Healthcare NHS Trust, Hammersmith Hospital, London, United Kingdom

⁵ University of Western Australia, Perth, Australia

⁶ Western Hospital, Footscray, Victoria, Australia

⁷ National Institute for Health Research University College London Hospitals Biomedical Research Centre, London, United Kingdom

⁸ Cancer Research United Kingdom–Medical Research Council Oxford Institute for Radiation Oncology, University of Oxford, Oxford, United Kingdom