RCTs - Protocols/Proposals (non-eHealth)

Novel Versus Conventional Sequencing of β-Blockers, Sodium/Glucose Cotransportor 2 Inhibitors, Angiotensin Receptor-Neprilysin Inhibitors, and Mineralocorticoid Receptor Antagonists in Stable Patients With Heart Failure With Reduced Ejection Fraction (NovCon Sequencing Study): Protocol for a Randomized Controlled Trial

Sumanth Karamchand, Tsungai Chipamaunga, Poobalan Naidoo, Kiolan Naidoo, Virendra Rambiritch, Kevin Ho, Robert Chilton, Kyle McMahon, Rory Leisegang, Hellmuth Weich, Karim Hassan

JMIR Res Protoc 2025 (Mar 10); 14:e44027

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Evaluation of the Efficacy of the Traditional Chinese Medicine Formulation Ru-Yi-Jin-Huang-Saan on Colles Fracture After Surgery: Protocol for a Randomized, Double-Blind, Placebo-Controlled Trial

Lien-Cheng Lin, Wei-Hsun Wang, Wei-Kai Chang, Jyun-Liang Gao, Ru-Chang Yang, Po-Chi Hsu, Lun-Chien Lo

JMIR Res Protoc 2025 (Mar 05); 14:e56849

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Auricular Acupressure Versus an Intermittent Low-Carbohydrate Diet in Children With Overweight or Obesity With Gastric-Heat and Dampness-Obstruction Syndrome: Protocol for a Randomized Controlled Trial

Wen Sun, Jingwei He, Wenqin Wang, Chen Lu, Yating Lin, Yalan Dou, Weili Yan, Jian Yu

JMIR Res Protoc 2025 (Mar 03); 14:e59856

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Neural Mechanism of Cognitive Reserve in Acupuncture Stimulation: Protocol for a Randomized, Placebo-Controlled Functional Near-Infrared Spectroscopy Trial

Hyeonsang Shin, Woohyun Seong, Yeonju Woo, Joo-Hee Kim, Kwang-Rak Park, Dong Hyuk Lee

JMIR Res Protoc 2025 (Feb 19); 14:e66838

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Effectiveness of Adaptation of a Resilience-Building Intervention Among Individuals With Adverse Childhood Experience: Protocol for a Randomized Controlled Trial

Jun Kiat, Mahadir Ahmad, Caryn Mei Hsien Chan, Satirah Zainalabidin, Michael Ungar, Ponnusamy Subramaniam

JMIR Res Protoc 2025 (Feb 12); 14:e56826

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Proposal and Strategy for Nursing-Led Research: Protocol for an Unfunded Clinical Trial

Leticia Carmen Simón-López, Ismael Ortuño-Soriano, Raquel Luengo-González, Paloma Posada-Moreno, Ignacio Zaragoza-García, Rubén Sánchez-Gómez

JMIR Res Protoc 2025 (Feb 10); 14:e56062

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ChatGPT-4 Performance on German Continuing Medical Education—Friend or Foe (Trick or Treat)? Protocol for a Randomized Controlled Trial

Christian Burisch, Abhav Bellary, Frank Breuckmann, Jan Ehlers, Serge C Thal, Timur Sellmann, Daniel Gödde

JMIR Res Protoc 2025 (Feb 06); 14:e63887

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Efficacy and Safety of Murivenna Anal Infiltration Compared to Diltiazem Topical Application in Chronic Anal Fissure: Protocol for a Prospective, Randomized, Open-Label Clinical Trial

Pratap Shankar KM, Indu Puthan Purayil, Palengara Binitha, Amit Kumar Rai, Sophia Jameela, Azeem Ahmad, Chandra Sekhara Rao Bhogavalli, Narayanam Srikanth, Rabinarayan Acharya

JMIR Res Protoc 2025 (Feb 03); 14:e63063

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Impact of the Mediterranean Diet on Patients With Psoriasis: Protocol for a Randomized Controlled Trial

Javier Perez-Bootello, Emilio Berna-Rico, Carlota Abbad-Jaime de Aragon, Ruth Cova-Martin, Leticia Goni, Asuncion Ballester-Martinez, Pedro Jaen-Olasolo, Nehal Mehta, Joel M Gelfand, Miguel Angel Martinez-Gonzalez, Alvaro Gonzalez-Cantero

JMIR Res Protoc 2025 (Jan 29); 14:e64277

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Evaluating the Effectiveness of a Multimodal Psychotherapy Training Program for Medical Students in China: Protocol for a Randomized Controlled Trial

Tao Pei, Yinan Ding, Jinsong Tang, Yanhui Liao

JMIR Res Protoc 2025 (Jan 03); 14:e58037

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Improving Oral Health in Prisons (PriOH): Protocol for a Randomized Controlled Trial

Emilie Bryne, Kathrine Høyvik Bergum, William Gilje Gjedrem

JMIR Res Protoc 2024 (Dec 11); 13:e60817

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Remotely Delivered Video Interaction Guidance for Families of Children With an Intellectual Disability Referred to Specialist Mental Health Services: Protocol for a Feasibility Randomized Controlled Trial

Charmaine Kohn, Lauren Turner, Zhixing Yang, Michael Absoud, Angela Casbard, Manuel Gomes, Gemma Grant, Angela Hassiotis, Eilis Kennedy, Sophie Levitt, Rachel McNamara, Elizabeth Randell, Vasiliki Totsika

JMIR Res Protoc 2024 (Dec 05); 13:e54619

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Influence of Distraction Factors on Performance in Laparoscopic Surgery in Immersive Virtual Reality: Study Protocol of a Cross-Over Trial in Medical Students and Residents—DisLapVR

Laura Hanke, Richard Schulte, Christian Boedecker, Florentine Huettl, Patrick Saalfeld, Vuthea Chheang, Marlene Wessels, Christoph von Castell, Heiko Hecht, Christian Hansen, Hauke Lang, Tobias Huber

JMIR Res Protoc 2024 (Nov 05); 13:e59014

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Impact of Dance or Music and Meditation on the Progression of Parkinson Disease With Mild or Moderate Severity: Protocol for a Pilot Randomized Controlled Trial

Bhagyashree Mehrotra, Neha Rai, Rajani MR, Aparna Budhakar, Ritika Aggarwal, Raj Vinodkumar Agarbattiwala, Mona Thomas, Sampada Patole, Paresh Doshi

JMIR Res Protoc 2024 (Oct 29); 13:e59018

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High Potassium Diet Rich in Spices and Herbs-Salt Substitution (HPSH-SS) for Blood Pressure Reduction in Older Adults: Protocol for Diet Concept and Randomized Controlled Trial

Farapti Farapti, Sheila Amara Putri, Annisaa Wulida Furqonia, Purwo Sri Rejeki, Muhammad Miftahussurur

JMIR Res Protoc 2024 (Oct 29); 13:e56869

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Over-the-Counter Hearing Aids Versus Traditional Hearing Aids in Patients With Mild-to-Moderate Hearing Loss: Protocol for a Noninferiority Randomized Controlled Trial

Ga-Young Kim, Mini Jo, Young Sang Cho, Il Joon Moon

JMIR Res Protoc 2024 (Oct 25); 13:e59894

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Acupuncture as Adjuvant Therapy for Glaucoma: Protocol for a Randomized Controlled Trial

Yi-Fang Liao, Yu-Chen Lee, Hui-Ju Lin, Yi-Ching Shao

JMIR Res Protoc 2024 (Oct 08); 13:e57888

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Graded Intensity Aerobic Exercise to Improve Cerebrovascular Function and Performance in Older Veterans: Protocol for a Randomized Controlled Trial

Medina Oneyi Bello, Kevin Michael Mammino, Mark Anthony Vernon, Daniel G Wakeman, Chanse Aerius Denmon, Lisa Crystal Krishnamurthy, Venkatagiri Krishnamurthy, Keith Matthew McGregor, Thomas Samuel Novak, Joe Robert Nocera

JMIR Res Protoc 2024 (Sep 26); 13:e58316

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Ayurveda Management of Allergic Rhinitis: Protocol for a Randomized Controlled Trial

Shweta Mata, Shivshankar Rajput, Isha Preet Tuli, Pallavi Mundada, Bharti Gupta, Narayanam Srikanth, Rabinarayanan Acharya

JMIR Res Protoc 2024 (Sep 25); 13:e56063

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Peer Intervention to Link Overdose Survivors to Treatment (PILOT): Protocol for a Multisite, Randomized Controlled Trial Conducted Within the National Institute on Drug Abuse Clinical Trials Network

Carrie Papa, Erin A McClure, Jenna McCauley, Louise Haynes, Timothy Matheson, Richard Jones, Lindsey Jennings, Tricia Lawdahl, Ralph Ward, Kathleen Brady, Kelly Stephenson Barth

JMIR Res Protoc 2024 (Sep 17); 13:e60277

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