RCTs - Protocols/Proposals (non-eHealth)

Comparison of Uncemented and Hybrid Hip Arthroplasty: Protocol for a Brazilian Randomized Controlled Trial

Bruno Gonçalves Schroder e Souza, Isabella Dias Lacerda, Matheus Malta Vasconcelos, Nathália Lacerda Furtado, Julia Machado Vieira, Iasmim Sand Ferreira de Souza, Marco Antônio Perígolo Magalhães, Leonã Aparecido Homem do Amaral, Luiz Guilherme Vidal Assad, Carlos Henrique Cavaglieri Silveira Silva, Carolina Tsen, Valdeci Manoel de Oliveira

JMIR Res Protoc 2026 (Mar 16); 15:e79721

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Clinical Efficacy Evaluation of Tuina Combined Medicated Oil in the Treatment of Nonspecific Low Back Pain: Protocol for a Randomized Controlled Trial

Man Yuan, Guangxin Guo, Siyu Wang, Fei Yao, Guimao Wang, Hongxi Xu

JMIR Res Protoc 2026 (Mar 11); 15:e81887

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Kidney-Tonifying, Phlegm-Resolving, and Blood Stasis–Removing Therapy for Multiple Myeloma: Protocol for a Randomized Controlled Trial on Epigenetic and Immune Modulation

Xiaoqi Sun, Yongming Zhou, Yujue Wang, Youya Dai, Wenwei Zhu, Hailin Chen

JMIR Res Protoc 2026 (Mar 05); 15:e86322

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Effects of Elastic Tape Associated With Pulmonary Rehabilitation in Male Individuals With Chronic Obstructive Pulmonary Disease: Protocol for a 2-Arm, Assessor-Blinded Randomized Controlled Trial

Thiago Fernandes Pinto, Juliana de Melo Batista dos Santos, Estéfane Caroline Monteiro Reis, Cibele C Berto Marques da Silva, Fabiano Francisco de Lima, Regina Maria Carvalho-Pinto, Celso Ricardo Fernandes Carvalho

JMIR Res Protoc 2026 (Feb 27); 15:e75029

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Validating a Multibiomarker Panel for the Assessment of Quantity and Quality of Plant Foods in the Diet (PLAENTI): Protocol for a Parallel Group–Designed Randomized Controlled Trial

Victor Schmalle, Julia Renz, Paola G Ferrario, Stephanie Seifert, Ann Katrin Engelbert, Oliver Wittek, Benedikt Merz, Lorraine Brennan, Claudine Manach, Manuela J Rist, Achim Bub

JMIR Res Protoc 2026 (Feb 27); 15:e77571

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Determining the Impact of a Physiotherapist-Led Primary Care Model for Low Back Pain: Protocol and Analysis Plan for a Cluster Randomized Controlled Trial and Embedded Process Evaluation

Jordan Miller, Catherine Donnelly, Chad McClintock, Kevin Varette, Yeimi Camargo, Jacquelyn Marsh, Monica Taljaard, Mir Sanim Al Mamun, Geneviève Bacchus, David Barber, Lynn Cooper, Simon French, Jonathan Hill, Michael Green, Joy MacDermid, Kathleen Norman, Julie Richardson, Joan Tranmer, Timothy Wideman

JMIR Res Protoc 2026 (Feb 26); 15:e89004

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Impact of Ocular Massage on Intraocular Pressure and Schlemm Canal Dimensions in Healthy Adults: Protocol for a Randomized Controlled Trial

Mingxuan Zhang, Luning Qin, Liangzhang Tan, Yongtao Li, Qing Zhang, Shuhan Wang, Zhihui Zhang, Emmanuel Eric Pazo, Xinjun Ren

JMIR Res Protoc 2026 (Feb 26); 15:e78864

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Urban Care Farming to Enhance Quality of Life Among Older Adults: Protocol for a Waitlist Randomized Trial

Cynthia Chen, Jocelin Lam, Zhenye Shi, Katika Akksilp, Su Aw, Mary Foong-Fong Chong, Choon Nam Ong, Angelia Sia, Leng Leng Thang, Xin Kai Tham, JunXiang Pong, Kartini Omar, Joan Hung, Marek Kukumberg, Roger Ho, Elizabeth Diehl

JMIR Res Protoc 2026 (Feb 25); 15:e78584

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Diffusion Tensor Imaging in the Diagnosis of Perianal Abscess: Protocol for a Single-Blind Randomized Controlled Trial

Yuting Ma, Pingping Mei, Xiutian Guo, Yan Chen

JMIR Res Protoc 2026 (Feb 25); 15:e83449

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Online Personalized Normative Feedback to Foster Intention to Change and Help Seeking in Young Adults With Disordered Gambling and Trading Behaviors: Protocol for a Randomized Controlled Trial

Ainhoa Coloma-Carmona, José Luis Carballo, Fernando Miró-Llinares, Virtudes Pérez-Jover

JMIR Res Protoc 2026 (Feb 23); 15:e73155

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Effects of Allulose vs Aspartame Consumption on Postprandial Glucagon-Like Peptide-1 Profiles and Metabolic Health: Protocol for a Randomized, Crossover, Double-Blind, Placebo-Controlled Trial

Selina Busch, Paola G Ferrario, Ann-Kathrin Henk, Ann Katrin Engelbert, Oliver Wittek, Stephanie Seifert, Achim Bub, Carina I Mack, Bettina Hieronimus

JMIR Res Protoc 2026 (Feb 19); 15:e81857

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Immediate and Sustained Effects of Intensive Equine-Assisted Physiotherapy Based on Neuroproprioceptive “Facilitation and Inhibition” on Psychomotor Development, Clinical Functions, Quality of Life, and Molecular Biological Indicators in Children With Spinal Muscular Atrophy: Protocol for a Crossover Randomized Controlled Trial

Katerina Marikova, Jindra Reissigova, Miloslav Vilimek, Marie Cerna, Marketa Pokorna, Kamila Rasova

JMIR Res Protoc 2026 (Feb 19); 15:e83266

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Evaluation of the Effectiveness of Injectable Platelet-Rich Fibrin as an Adjuvant to One-Stage Full-Mouth Disinfection in Patients with Stage II and III Periodontitis: Protocol for a Randomized Clinical Trial

Mahima Kothekar, Pavan Bajaj, Sneha Dare, Shivani Thakre

JMIR Res Protoc 2026 (Feb 19); 15:e81032

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Impact of the Population Medicine Multimorbidity Intervention in Xishui County (POPMIX) on People at High Risk for Chronic Obstructive Pulmonary Disease: Protocol for the POPMIX-COPD Cluster Randomized Controlled Trial

Chen Wang, Yuhao Liu, Ke Huang, Zhoutao Zheng, Shiyu Zhang, Wenjin Chen, Xingyao Tang, Zhong Cao, Xunliang Tong, Lei Tang, Jinghan Zhao, Liu He, Lirui Jiao, Yingping Wang, Tianying Zhao, Yingchi Luo, Qiande Lai, Xiangqin Lyu, Qiushi Chen, Aditi Bunker, Sebastian Vollmer, Pascal Geldsetzer, Dean Jamison, Till Bärnighausen, Ting Yang, Simiao Chen, POPMIX Group

JMIR Res Protoc 2026 (Feb 18); 15:e85597

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Efficacy of Tuina for Myopia in Children: Protocol for a Randomized Controlled Trial

Shouyao Zhang, Yanju Han, Lijuan Zhang, Fang Tan, Xueping Huang, Can Zhang, Zheng Yao, Lei Xiong, Xiantao Tai

JMIR Res Protoc 2026 (Feb 12); 15:e79324

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Effect of Du-Moxibustion Combined With Spine-Pinching Therapy on Cognitive Frailty in Older Adults With Prefrailty: Protocol for a Randomized Controlled Trial

Suzhen Liu, Mengxia Qi, Hua-Fang Li, Ziqiu Ye, Yu Xu, Xiangying Yang

JMIR Res Protoc 2026 (Feb 10); 15:e82683

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Effects of Acupuncture-Combined Tuina on Patients With Knee Osteoarthritis: Protocol for a Randomized Controlled Trial

Chendong Gu, Dong Wei, Kaiyue Zhang, Jinxi Ren, Yihui Qiao, Fengyu Zhang, Yiting Zhu, Zhixian Xu, Yinlong Cao, Shuyi Yao, Hanrui Guo, Yihang Wang, Huan Wang, Lin Wang, Quanliang Wang, Guangxin Guo

JMIR Res Protoc 2026 (Feb 05); 15:e84082

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Enhancing Upper Secondary Students’ Situational Engagement and Cognitive Prerequisites of Learning Through the Physically Active Academic Lessons Intervention: Protocol for a Mixed Methods Cluster Randomized Individual Crossover Trial

Heidi J Syväoja, Susanna Takalo, Tuomas Kukko, Nina Salmela, Harto Hakonen, Janne Kulmala, Heidi Lindfors, Hermanni Oksanen, Pekka Räsänen, Kati Mäkitalo, Tuija H Tammelin

JMIR Res Protoc 2026 (Feb 03); 15:e84601

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Efficacy of Acupuncture for Mild to Moderate Depression in Older People: Protocol for a Randomized Controlled Trial

Qingnan Fu, Kaihui Xiao, Jie Zhang, Yang Li, Yuxian Wang, Molin Jiang, Zengqi Man, Jing Yang, Wei Lu

JMIR Res Protoc 2026 (Jan 30); 15:e79327

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Brief Intervention for Discontinuing Inappropriate Z-Hypnotic Use Among Older Patients in Primary Care: Protocol for a Cluster Randomized Controlled Trial With a Single Crossover

Tahreem Ghazal Siddiqui, Maria Torheim Bjelkarøy, Tone Breines Simonsen, Maria Lie Selle, Christofer Lundqvist

JMIR Res Protoc 2026 (Jan 30); 15:e75670

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