Combination Analgesic Development for Enhanced Clinical Efficacy (CADENCE Trial): Study Protocol for a Double-Blind, Randomized, Placebo-Controlled Crossover Trial of an Alpha-Lipoic Acid – Pregabalin Combination for the Treatment of Fibromyalgia Pain

Ian Gilron   ¹ , MSc, MD ;   Dongsheng Tu   ² , PhD ;   Ronald Holden   ² , PhD ;   Tanveer Towheed   ² , MD ;   Elizabeth Vandenkerkhof   ² , DrPH ;   Roumen Milev   ² , MD, PhD

¹ Queen's University, Department of Anesthesiology and Perioperative Medicine, Queen's University, Kingston, ON, Canada

² Division of Cancer Care and Epidemiology, Queen's Cancer Research Institute, Kingston, ON, Canada