The Paget Trial: A Multicenter, Observational Cohort Intervention Study for the Clinical Efficacy, Safety, and Immunological Response of Topical 5% Imiquimod Cream for Vulvar Paget Disease

Michelle van der Linden   ¹ , MD ;   Kim Meeuwis   ² , MD, PhD ;   Colette van Hees   ³ , MD ;   Eleonora van Dorst   ⁴ , MD ;   Johan Bulten   ⁵ , MD, PhD ;   Tjalling Bosse   ⁶ , MD, PhD ;   Joanna IntHout   ⁷ , PhD ;   Dorry Boll   ⁸ , MD, PhD ;   Brigitte Slangen   ⁹ , MD, PhD ;   Manon van Seters   ¹⁰ , MD, PhD ;   Marc van Beurden   ¹¹ , MD, PhD ;   Mariëtte van Poelgeest   ¹² , MD, PhD ;   Joanne de Hullu   ¹ , MD, PhD

¹ Department of Obstetrics and Gynaecology, Radboud University Medical Center, Nijmegen, Netherlands

² Department of Dermatology, Radboud University Medical Center, Nijmegen, Netherlands

³ Department of Dermatology, Erasmus Medical Center, Rotterdam, Netherlands

⁴ Department of Gynaecology, University Medical Center Utrecht, Utrecht, Netherlands

⁵ Department of Pathology, Radboud University Medical Center, Nijmegen, Netherlands

⁶ Department of Pathology, Leiden University Medical Center, Leiden, Netherlands

⁷ Department for Health Evidence, Radboud Institute for Health Sciences, Nijmegen, Netherlands

⁸ Department of Gynaecology, Catharina Hospital, Eindhoven, Netherlands

⁹ Department of Gynaecology, Maastricht University Medical Center, Maastricht, Netherlands

¹⁰ Department of Obstetrics & Gynaecology, Worchester Royal Hospital, Worchester, United Kingdom

¹¹ Department of Gynaecology, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, Netherlands

¹² Department of Gynaecology, Leiden University Medical Center, Leiden, Netherlands