Early Detection of Cardiovascular Changes After Radiotherapy for Breast Cancer: Protocol for a European Multicenter Prospective Cohort Study (MEDIRAD EARLY HEART Study)

Valentin Walker   ¹ , MSc ;   Anne Crijns   ² , MD, PhD ;   Johannes Langendijk   ² , MD, PhD ;   Daan Spoor   ² , MSc ;   Rozemarijn Vliegenthart   ³ , MD, PhD ;   Stephanie E Combs   ^{4, 5, 6} , MD, PhD ;   Michael Mayinger   ⁴ , MD ;   Arantxa Eraso   ⁷ , MD, PhD ;   Ferran Guedea   ⁸ , MD, PhD ;   Manuela Fiuza   ⁹ , MD, PhD ;   Susana Constantino   ¹⁰ , PhD ;   Radia Tamarat   ¹¹ , PhD ;   Dominique Laurier   ¹² , PhD ;   Jean Ferrières   ^{13, 14} , MD, PhD ;   Elie Mousseaux   ¹⁵ , MD, PhD ;   Elisabeth Cardis   ^{16, 17, 18} , PhD ;   Sophie Jacob   ¹ , PhD

¹ Pôle Santé-Environnement (PSE-SANTE), Service de recherche sur les effets biologiques et sanitaires des rayonnements ionisants (SESANE), Laboratoire d'épidémiologie des rayonnements ionisants (LEPID), Institut de Radioprotection et de Sûreté Nucléaire (IRSN), Fontenay-aux-Roses, France

² Department of Radiation Oncology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands

³ Center for Medical Imaging, Department of Radiology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands

⁴ Department of Radiation Oncology, Technische Universität München (TUM), München, Germany

⁵ Department of Radiation Sciences (DRS), Institute of Innovative Radiotherapy (iRT), Helmholtz Zentrum München (HMGU), München, Germany

⁶ Deutsches Konsortium für Translationale Krebsforschung (DKTK), Partner Site Munich, München, Germany

⁷ Department of Radiation Oncology, Institut Català d'Oncologia, Girona, Spain

⁸ Department of Radiation Oncology, Institut Català d'Oncologia, L’Hospitalet del Llobregat, Spain

⁹ Department of Cardiology, Centro Cardiovascular da Universidade de Lisboa, Lisbon, Portugal

¹⁰ Laboratory of Angiogenesis, Centro Cardiovascular da Universidade de Lisboa, Lisbon, Portugal

¹¹ Pôle Santé-Environnement (PSE-SANTE), Institut de Radioprotection et de Sûreté Nucléaire (IRSN), Fontenay-aux-Roses, France

¹² Pôle Santé-Environnement (PSE-SANTE), Service de recherche sur les effets biologiques et sanitaires des rayonnements ionisants (SESANE), Institut de Radioprotection et de Sûreté Nucléaire (IRSN), Fontenay-aux-Roses, France

¹³ Department of Cardiology B and Epidemiology, University Hospital, Toulouse, France

¹⁴ Unite Mixte de Recherche (UMR) 1027, The Institut national de la santé et de la recherche médicale (INSERM), Toulouse, France

¹⁵ Department of Radiology, Hôpital Européen Georges Pompidou, Paris Descartes University, Paris, France

¹⁶ Institute for Global Health (ISGlobal), Radiation Programme, Barcelona Biomedical Research Park (PRBB), Barcelona, Spain

¹⁷ Pompeu Fabra University (UPF), Barcelona, Spain

¹⁸ Consorcio Centro de Investigación Biomédica en Red Epidemiologia y Salud Pública (CIBERESP), Madrid, Spain