Treatment with Creatine Monohydrate in Spinal and Bulbar Muscular Atrophy: Protocol for a Randomized, Double-Blind, Placebo-Controlled Trial

Yasuhiro Hijikata   ¹ , MD, PhD ;   Masahisa Katsuno   ^{1 *} , MD, PhD ;   Keisuke Suzuki   ^{1, 2} , MD, PhD ;   Atsushi Hashizume   ¹ , MD, PhD ;   Amane Araki   ¹ , MD, PhD ;   Shinichiro Yamada   ¹ , MD, PhD ;   Tomonori Inagaki   ¹ , MD ;   Daisuke Ito   ¹ , MD ;   Akihiro Hirakawa   ³ , PhD ;   Fumie Kinoshita   ³ , MSc ;   Masahiko Gosho   ⁴ , PhD ;   Gen Sobue   ^{1, 5 *} , MD, PhD

¹ Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, Japan

² Innovation Center for Clinical Research, National Center for Geriatnics and Gerontology, Obu, Japan

³ Biostatistics Section, Center for Advanced Medicine and Clinical Research, Nagoya University Graduate School of Medicine, Nagoya, Japan

⁴ Department of Clinical Trial and Clinical Epidemiology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan

⁵ Research Division of Dementia and Neurodegenerative Disease, Nagoya University Graduate School of Medicine, Nagoya, Japan

*these authors contributed equally