Genetic Determinants of Ototoxicity During and After Childhood Cancer Treatment: Protocol for the PanCareLIFE Study

Eva Clemens   ^{1, 2 *} , MSc ;   Annelot JM Meijer   ^{1 *} , MSc ;   Linda Broer   ³ , PhD ;   Thorsten Langer   ⁴ , MD, PhD ;   Anne-Lotte LF van der Kooi   ^{1, 2, 5} , MSc, MD ;   André G Uitterlinden   ³ , PhD ;   Andrica de Vries   ^{1, 2} , MD, PhD ;   Claudia E Kuehni   ^{6, 7} , MD, PhD ;   Maria L Garrè   ⁸ , MD ;   Tomas Kepak   ^{9, 10} , MD ;   Jarmila Kruseova   ¹¹ , MD ;   Jeanette F Winther   ^{12, 13} , MD ;   Leontien C Kremer   ^{1, 14} , MD, PhD ;   Eline van Dulmen-den Broeder   ^{1, 15} , PhD ;   Wim JE Tissing   ^{1, 16} , MD, PhD ;   Catherine Rechnitzer   ¹⁷ , MSc, MD ;   Line Kenborg   ¹² , PhD ;   Henrik Hasle   ¹⁸ , MD, PhD ;   Desiree Grabow   ¹⁹ , PhD ;   Ross Parfitt   ²⁰ , PhD ;   Harald Binder   ^{19, 21} , PhD ;   Bruce C Carleton   ²² , PharmD ;   Julianne Byrne   ²³ , PhD ;   Peter Kaatsch   ¹⁹ , PhD ;   Antoinette am Zehnhoff-Dinnesen   ²⁰ , AuD ;   Oliver Zolk   ²⁴ , PhD ;   Marry M van den Heuvel-Eibrink   ¹ , MD, PhD

¹ Princess Maxima Center for Pediatric Oncology, Utrecht, Netherlands

² Department of Pediatric Hematology and Oncology, Erasmus Medical Center–Sophia Children's Hospital, Rotterdam, Netherlands

³ Department of Internal Medicine, Erasmus Medical Center, Rotterdam, Netherlands

⁴ Department of Pediatric Oncology, University Hospital for Children and Adolescents, Luebeck, Germany

⁵ Department of Obstetrics and Gynecology, Erasmus Medical Center–Sophia Children's Hospital, Rotterdam, Netherlands

⁶ Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland

⁷ Department of Paediatric Respiratory Medicine, University Children's Hospital, University of Bern, Bern, Switzerland

⁸ Department of Neurooncology, Institute Giannina Gaslini, Genova, Italy

⁹ Department of Paediatric Oncology, University Hospital Brno, Masaryk University, Brno, Czech Republic

¹⁰ St. Anne’s University Hospital Brno–International Clinical Research Center, Brno, Czech Republic

¹¹ Department of Pediatric Hemato-Oncology, Motol University Hospital Prague, Prague, Czech Republic

¹² Danish Cancer Society Research Center, Copenhagen, Denmark

¹³ Department of Clinical Medicine, Faculty of Health, Aarhus University, Aarhus, Denmark

¹⁴ Department of Pediatric Oncology, Academic Medical Center Amsterdam, Amsterdam, Netherlands

¹⁵ Department of Pediatric Hematology and Oncology, VU Medical Center, Amsterdam, Netherlands

¹⁶ Department of Pediatric Oncology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands

¹⁷ Department of Pediatrics and Adolescent Medicine, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark

¹⁸ Department of Pediatrics, Aarhus University Hospital, Aarhus, Denmark

¹⁹ German Childhood Cancer Registry, Institute of Medical Biostatistics, Epidemiology and Informatics, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany

²⁰ Department of Phoniatrics and Pedaudiology, University of Münster, Muenster, Germany

²¹ Institute of Medical Biometry and Statistics, Faculty of Medicine and Medical Center, University of Freiburg, Freibug, Germany

²² Division of Translational Therapeutics, Department of Pediatrics, British Columbia Children’s Hospital Research Institute, University of British Columbia, Vancouver, BC, Canada

²³ Boyne Research Institute, Drogheda, Ireland

²⁴ Institute of Pharmacology of Natural Products and Clinical Pharmacology, Ulm University Medical Center, Ulm, Germany

*these authors contributed equally