Exploring the Paradoxical Relationship of a Creb 3 Regulatory Factor Missense Variant With Body Mass Index and Diabetes Among Samoans: Protocol for the Soifua Manuia (Good Health) Observational Cohort Study

Nicola L Hawley   ¹ , BSc, PhD ;   Alysa Pomer   ¹ , BA, MA, MS, PhD ;   Anna C. Rivara   ¹ , BS, MA, MPH, PhD ;   Samantha L Rosenthal   ² , BA, PhD ;   Rachel L Duckham   ^{3, 4} , BS, MS, PhD ;   Jenna C Carlson   ⁵ , BS, PhD ;   Take Naseri   ⁶ , BSc, MD, MPH ;   Muagututia Sefuiva Reupena   ⁷ , BA, MA ;   Melania Selu   ⁸ ;   Vaimoana Lupematisila   ⁸ ;   Folla Unasa   ⁸ ;   Lupesina Vesi   ⁸ ;   Tracy Fatu   ⁸ ;   Seipepa Unasa   ⁸ ;   Kima Faasalele-Savusa   ⁸ , BM ;   Abigail I Wetzel   ⁹ , BS ;   Christina Soti-Ulberg   ⁶ , BSc ;   Angela T Prescott   ¹⁰ , BA, MD ;   Gloria Siufaga   ⁸ ;   Corina Penaia   ¹¹ , BA ;   Sophie B. To   ¹² , BA, MPH ;   Lauren C LaMonica   ¹ , BA, MPH ;   Viali Lameko   ¹³ , BSc, MD, MPH ;   Courtney C Choy   ⁹ , BA, MPH ;   Scott E Crouter   ¹⁴ , BS, MS, PhD ;   Susan Redline   ¹⁵ , BA, MD, MPH ;   Ranjan Deka   ¹⁶ , PhD ;   Erin E Kershaw   ^{17 *} , BA, MD ;   Zsolt Urban   ^{2 *} , MS, PhD ;   Ryan L. Minster   ^{2 *} , BS, MSIS, PhD ;   Daniel E. Weeks   ^{2 *} , BA, MS, PhD ;   Stephen T McGarvey   ^{9, 18 *} , BA, MA, PhD, MPH

¹ Department of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, CT, United States

² Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, United States

³ Institute of Physical Activity and Nutrition, Deakin University, Geelong, Australia

⁴ Australian Institute for Musculoskeletal Sciences, The University of Melbourne and Western Health, St Albans, Australia

⁵ Department of Biostatistics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, United States

⁶ Ministry of Health, Apia, Samoa

⁷ Lutia I Puava Ae Mapu I Fagalele, Apia, Samoa

⁸ Obesity, Lifestyle and Genetic Adaptations Study Group, Apia, Samoa

⁹ International Health Institute, Department of Epidemiology, School of Public Health, Brown University, Providence, RI, United States

¹⁰ Department of Plastic and Reconstructive Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, United States

¹¹ Asian Pacific Islander Forward Movement, Los Angeles, CA, United States

¹² Department of Social and Behavioral Sciences, Yale School of Public Health, New Haven, CT, United States

¹³ Oceania University of Medicine, Apia, Samoa

¹⁴ Department of Kinesiology, Recreation, and Sport Studies, The University of Tennessee Knoxville, Knoxville, TN, United States

¹⁵ Departments of Medicine, Brigham and Women's Hospital and Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States

¹⁶ Department of Environmental Health, College of Medicine, University of Cincinnati, Cincinnati, OH, United States

¹⁷ Division of Endocrinology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, United States

¹⁸ Department of Anthropology, Brown University, Providence, RI, United States

*these authors contributed equally