A Novel HIV-1 RNA Testing Intervention to Detect Acute and Prevalent HIV Infection in Young Adults and Reduce HIV Transmission in Kenya: Protocol for a Randomized Controlled Trial

Susan M Graham   ^{1, 2, 3} , MD, MPH, PhD ;   Clara Agutu   ⁴ , MBChB, MPH, MSc ;   Elise van der Elst   ⁴ , PhD ;   Amin S Hassan   ⁴ , MSc, PhD ;   Evanson Gichuru   ⁴ , BSc ;   Peter M Mugo   ⁴ , BPharm, MSc, PhD ;   Carey Farquhar   ^{1, 2, 3} , MD, MPH ;   Joseph B Babigumira   ^{1, 5} , MBChB, MS, PhD ;   Steven M Goodreau   ^{3, 6} , MA, PhD ;   Deven T Hamilton   ⁷ , MPH, PhD ;   Thumbi Ndung'u   ^{8, 9, 10, 11} , PhD ;   Martin Sirengo   ¹² , MBChB ;   Wairimu Chege   ¹³ , MD, MPH ;   Eduard J Sanders   ^{4, 14} , MD, MPH, PhD

¹ Department of Global Health, University of Washington, Seattle, WA, United States

² Department of Medicine, University of Washington, Seattle, WA, United States

³ Department of Epidemiology, University of Washington, Seattle, WA, United States

⁴ Kenya Medical Research Institute - Wellcome Trust Research Programme, Kilifi, Kenya

⁵ Department of Pharmacy, University of Washington, Seattle, WA, United States

⁶ Department of Anthropology, University of Washington, Seattle, WA, United States

⁷ Center for Studies in Demography and Ecology, University of Washington, Seattle, WA, United States

⁸ Africa Health Research Institute, Durban, South Africa

⁹ HIV Pathogenesis Programme, Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban, South Africa

¹⁰ Max Planck Institute for Infection Biology, Berlin, Germany

¹¹ Division of Infection and Immunity, University College London, London, United Kingdom

¹² Department of Health Infrastructure Management, Ministry of Health, Nairobi, Kenya

¹³ Division of AIDS, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, United States

¹⁴ University of Oxford, Headington, United Kingdom