Identification of Genetic Predispositions Related to Ionizing Radiation in Primary Human Skin Fibroblasts From Survivors of Childhood and Second Primary Cancer as Well as Cancer-Free Controls: Protocol for the Nested Case-Control Study KiKme

Manuela Marron   ¹ , PhD ;   Lara Kim Brackmann   ¹ , MSc ;   Heike Schwarz   ¹ , PhD ;   Willempje Hummel-Bartenschlager   ¹ ;   Sebastian Zahnreich   ² , PhD ;   Danuta Galetzka   ² , PhD ;   Iris Schmitt   ² , MSc ;   Christian Grad   ² , MD ;   Philipp Drees   ³ , Prof Dr ;   Johannes Hopf   ³ , MD ;   Johanna Mirsch   ⁴ , PhD ;   Peter Scholz-Kreisel   ⁵ , PhD ;   Peter Kaatsch   ⁶ , PhD ;   Alicia Poplawski   ⁵ , PhD ;   Moritz Hess   ⁷ , PhD ;   Harald Binder   ⁷ , Prof Dr ;   Thomas Hankeln   ⁸ , Prof Dr ;   Maria Blettner   ⁵ , Prof Dr ;   Heinz Schmidberger   ² , Prof Dr

¹ Leibniz Institute for Prevention Research and Epidemiology – BIPS, Bremen, Germany

² Department of Radiation Oncology and Radiation Therapy, University Medical Center of the Johannes Gutenberg University, Mainz, Germany

³ Department of Orthopedics and Traumatology, University Medical Center of the Johannes Gutenberg University, Mainz, Germany

⁴ Radiation Biology and DNA Repair, Technical University of Darmstadt, Darmstadt, Germany

⁵ Institute of Medical Biostatistics, Epidemiology and Informatics, University Medical Center of the Johannes Gutenberg University, Mainz, Germany

⁶ German Childhood Cancer Registry, Institute for Medical Biostatistics, Epidemiology and Informatics, University Medical Center of the Johannes Gutenberg University, Mainz, Germany

⁷ Institute of Medical Biometry and Statistics, Faculty of Medicine and Medical Center Freiburg, University of Freiburg, Freiburg, Germany

⁸ Institute of Organismic and Molecular Evolution, Molecular Genetics and Genome Analysis, Johannes Gutenberg University, Mainz, Germany