Valproic Acid as an Adjuvant Treatment for Generalized Convulsive Status Epilepticus in Adults Admitted to Intensive Care Units: Protocol for a Double-Blind, Multicenter Randomized Controlled Trial

Tarek Sharshar   ^{1, 2} , PhD, MD ;   Omar Ben Hadj Salem   ³ , MD ;   Raphaël Porcher   ^{2, 4} , PhD ;   Lamiae Grimaldi-Bensouda   ⁵ , PhD, PharmD ;   Nicholas Heming   ⁶ , PhD, MD ;   Bernard Clair   ⁶ , MD ;   Eric Azabou   ⁶ , PhD, MD ;   Aurélien Mazeraud   ^{1, 2} , PhD, MD ;   Benjamin Rohaut   ^{7, 8} , PhD, MD ;   Hervé Outin   ³ , MD

¹ Groupement Hospitalo-Universitaire Paris Psychiatrie et Neurosciences, Paris, France

² Université de Paris, Paris, France

³ Centre Hospitalier Poissy Saint Germain en Laye, Poissy, France

⁴ Center for Clinical Epidemiology, Assistance Publique Hôpitaux de Paris, Hôtel Dieu Hospital, Paris, France

⁵ Clinical Research Unit, Ambroise Paré Hospital, University of Versailles Saint-Quentin en Yvelines, Saint-Quentin en Yveline, France

⁶ Centre Hospitalo-Universitaire Raymond Poincaré, Assistance de Paris - Hôpitaux de Paris, Garches, France

⁷ Centre Hospitalo-Universitaire Pitié Salpétrière, Paris, France

⁸ Sorbonne Université, Paris, France