Optimizing Oral Targeted Anticancer Therapies Study for Patients With Solid Cancer: Protocol for a Randomized Controlled Medication Adherence Program Along With Systematic Collection and Modeling of Pharmacokinetic and Pharmacodynamic Data

Carole Bandiera   ^{1, 2, 3 *} , PharmD ;   Evelina Cardoso   ^{4 *} , PharmD, PhD ;   Isabella Locatelli   ³ , MSc, PhD ;   Antonia Digklia   ⁵ , MD ;   Khalil Zaman   ⁵ , MD, PhD ;   Antonella Diciolla   ⁵ , MD ;   Valérie Cristina   ⁵ , MD ;   Athina Stravodimou   ⁵ , MD ;   Aedo Lopez Veronica   ⁵ , MSc ;   Ana Dolcan   ⁵ , MD ;   Apostolos Sarivalasis   ⁵ , MD ;   Aikaterini Liapi   ⁵ , MD ;   Hasna Bouchaab   ⁵ , MD ;   Angela Orcurto   ⁵ , MD ;   Jennifer Dotta-Celio   ³ , PharmD, PhD ;   Solange Peters   ⁵ , MD, PhD ;   Laurent Decosterd   ⁶ , PharmD, PhD ;   Nicolas Widmer   ^{2, 6, 7, 8} , PharmD, PhD ;   Dorothea Wagner   ⁵ , MD, PhD ;   Chantal Csajka   ^{2, 4, 7 *} , PharmD, PhD ;   Marie Paule Schneider   ^{1, 2 *} , PharmD, PhD

¹ School of Pharmaceutical Sciences, University of Geneva, Geneva, Switzerland

² Institute of Pharmaceutical Sciences of Western Switzerland, University of Geneva, Geneva, Switzerland

³ Center for Primary Care and Public Health (Unisanté), University of Lausanne, Lausanne, Switzerland

⁴ Center for Research and Innovation in Clinical Pharmaceutical Sciences, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland

⁵ Department of Oncology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland

⁶ Service of Clinical Pharmacology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland

⁷ School of Pharmaceutical Sciences, University of Lausanne, Lausanne, Switzerland

⁸ Pharmacy of the Eastern Vaud Hospitals, Rennaz, Switzerland

*these authors contributed equally