The Safety and Efficacy of Microbial Ecosystem Therapeutic-2 in People With Major Depression: Protocol for a Phase 2, Double-Blind, Placebo-Controlled Study

Arthi Chinna Meyyappan   ^{1, 2, 3, 4} , BScH, MSc ;   Cassandra Sgarbossa   ^{1, 2, 3} , BAH ;   Gustavo Vazquez   ^{1, 2, 3} , MD, PhD, FRCPC ;   David J Bond   ⁵ , MD, PhD ;   Daniel J Müller   ^{4, 6} , MD, PhD ;   Roumen Milev   ^{1, 2, 3, 7} , MD, PhD, FRCPC, FRCPysch

¹ Centre for Neuroscience Studies, Queen's University, Kingston, ON, Canada

² Providence Care Hospital, Kingston, ON, Canada

³ Department of Psychiatry, Queen's University, Kingston, ON, Canada

⁴ Centre for Addiction and Mental Health, Toronto, ON, Canada

⁵ Department of Psychiatry & Behavioral Sciences, University of Minnesota Medical School, Minneapolis, MN, United States

⁶ Department of Psychiatry, University of Toronto, Toronto, ON, Canada

⁷ Department of Psychology, Queen's University, Kingston, ON, Canada