A Digital Health Intervention for Stress and Anxiety Relief in Perioperative Care: Protocol for a Feasibility Randomized Controlled Trial

Haridimos Kondylakis   ^{1 *} , MSc, PhD ;   Irene Alice Chicchi Giglioli   ^{2 *} , PhD ;   Dimitrios G Katehakis   ^{1 *} , MSc, PMP ;   Hatice Aldemir   ^{3 *} , PhD ;   Paul Zikas   ^{4 *} , BSc, MSc ;   George Papagiannakis   ^{1, 5 *} , BEng, MSc, PhD ;   Santiago Hors-Fraile   ^{2 *} , MSc, PhD ;   Pedro L González-Sanz   ^{2 *} , MD ;   Konstantinos C Apostolakis   ^{1 *} , BSc ;   Constantine Stephanidis   ^{1, 5 *} , PhD ;   Francisco J Núñez-Benjumea   ^{6 *} , MSc ;   Rosa M Baños-Rivera   ^{7, 8 *} , PhD ;   Luis Fernandez-Luque   ^{2 *} , PhD ;   Angelina Kouroubali   ^{1 *} , PhD

¹ Institute of Computer Science, Foundation for Research and Technology (FORTH), Heraklion, Greece

² Adhera Health, Inc, Palo Alto, CA, United States

³ Digital Health Program, Barcelona Technology School, Barcelona University, Barcelona, Spain

⁴ ORamaVR SA, Heraklion, Greece

⁵ Department of Computer Science, University of Crete, Heraklion, Greece

⁶ Virgen Macarena University Hospital, Andalusian Health Service, Sevilla, Spain

⁷ Polibienestar Institute, University of Valencia, Valencia, Spain

⁸ CiberObn Pathophysiology of Obesity and Nutrition (CB06/03), Instituto Salud Carlos III, Madrid, Spain

*all authors contributed equally