Comparing Online and On-Site Cognitive Behavior Therapy in Major Depressive Disorder: Protocol for a Noninferiority Randomized Controlled Trial

Paul Ritvo   ¹ , PhD ;   David Gratzer   ² , MD ;   Yuliya Knyahnytska   ² , MD, PhD ;   Abigail Ortiz   ² , MD ;   Clarice Walters   ² , BSc ;   Joel Katz   ³ , PhD ;   Judith Laposa   ² , PhD ;   Christopher Baldissera   ² , MA ;   Noah Wayne   ^{1, 4} , PhD ;   Donna Pfefer-Litman   ² , MA ;   George Tomlinson   ³ , PhD ;   Zafiris Daskalakis   ⁵ , MD, PhD

¹ School of Kinesiology and Health Science, York University, Toronto, ON, Canada

² Centre for Addiction and Mental Health, Toronto, ON, Canada

³ Department of Medicine, University Health Network and Mt. Sinai Hospital, Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, ON, Canada

⁴ NexJ Health, Inc., Toronto, ON, Canada

⁵ Department of Psychiatry, University of California, San Diego, San Diego, CA, United States