Efficacy and Tolerability of Two Novel “Standard of Care” Treatments—Intranasal Esketamine Versus Intravenous Ketamine—for Treatment-Resistant Depression in Naturalistic Clinical Practice: Protocol for a Pilot Observational Study

Gilmar Gutierrez   ¹ , BSc ;   Joshua Rosenblat   ² , MD ;   Emily Hawken   ³ , MSc, PhD ;   Jennifer Swainson   ⁴ , MD ;   Gustavo Vazquez   ³ , MD, PhD

¹ School of Medicine, Faculty of Health Sciences, Queen's University, Kingston, ON, Canada

² Canadian Rapid Treatment Center of Excellence, Toronto, ON, Canada

³ Department of Psychiatry, Faculty of Health Sciences, Queen's University, Kingston, ON, Canada

⁴ Department of Psychiatry, University of Alberta, Edmonton, AB, Canada