Published on in Vol 11, No 7 (2022): July

Preprints (earlier versions) of this paper are available at https://preprints.jmir.org/preprint/37898, first published .
Intravenous Infusion of Autoserum-Expanded Autologous Mesenchymal Stem Cells in Patients With Chronic Brain Injury: Protocol for a Phase 2 Trial

Intravenous Infusion of Autoserum-Expanded Autologous Mesenchymal Stem Cells in Patients With Chronic Brain Injury: Protocol for a Phase 2 Trial

Intravenous Infusion of Autoserum-Expanded Autologous Mesenchymal Stem Cells in Patients With Chronic Brain Injury: Protocol for a Phase 2 Trial

Shinichi Oka   1, 2 , MD, PhD ;   Tomohiro Yamaki   3 , MD, PhD ;   Masanori Sasaki   1, 2, 4 , MD, PhD ;   Ryo Ukai   1 , MD, PhD ;   Mitsuhiro Takemura   1 , MD, PhD ;   Takahiro Yokoyama   1 , MD ;   Yuko Kataoka-Sasaki   1, 2 , MD, PhD ;   Rie Onodera   1 , PhD ;   Yoichi M Ito   5 , PhD ;   Shigeki Kobayashi   3 , MD, PhD ;   Jeffery D Kocsis   4, 6 , PhD ;   Yasuo Iwadate   7 , MD, PhD ;   Osamu Honmou   1, 2, 4 , MD, PhD

1 Department of Neural Regenerative Medicine, Research Institute for Frontier Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan

2 Department of Advanced Regenerative Therapeutics, Sapporo Medical University School of Medicine, Sapporo, Japan

3 Division of Neurosurgery, Rehabilitation Center for Traumatic Apallics Chiba, National Agency for Automotive Safety and Victims' Aid, Chiba, Japan

4 Department of Neurology, Yale University School of Medicine, New Haven, CT, United States

5 Data Science Center, Institute of Health Science Innovation for Medical Care, Hokkaido University Hospital, Sapporo, Japan

6 Department of Neuroscience, Yale University School of Medicine, New Haven, CT, United States

7 Department of Neurological Surgery, Chiba University Graduate School of Medicine, Chiba, Japan

Corresponding Author:

  • Masanori Sasaki, MD, PhD
  • Department of Neural Regenerative Medicine
  • Research Institute for Frontier Medicine
  • Sapporo Medical University School of Medicine
  • S1W17, Chuo-ku
  • Sapporo, 060-8556
  • Japan
  • Phone: 81 6112111
  • Fax: 81 6163112
  • Email: msasaki@sapmed.ac.jp