Dobutamine and Goal-Directed Fluid Therapy for Improving Tissue Oxygenation in Deep Inferior Epigastric Perforator (DIEP) Flap Breast Reconstruction Surgery: Protocol for a Randomized Controlled Trial

Glenio B Mizubuti   ¹ , MSc, MD ;   Anthony M-H Ho   ¹ , MD ;   Rachel Phelan   ¹ , MSc ;   Deborah DuMerton   ² , RN, CCRP ;   Jessica Shelley   ¹ , BNSc, RN, CCRP ;   Elorm Vowotor   ¹ , RN ;   Jessica Xiong   ^{1, 3} ;   Bethany Smethurst   ^{1, 3} , BHSc ;   Michael McMullen   ¹ , MD ;   Wilma M Hopman   ⁴ , MA ;   Glykeria Martou   ⁵ , MD ;   Robert Wesley Edmunds   ⁵ , MD ;   Robert Tanzola   ¹ , MD

¹ Department of Anesthesiology and Perioperative Medicine, Queen's University, Kingston, ON, Canada

² Department of Anesthesiology and Perioperative Medicine, Kingston Health Sciences Centre, Kingston, ON, Canada

³ Department of Biomedical and Molecular Sciences, School of Medicine, Queen's University, Kingston, ON, Canada

⁴ Kingston Health Sciences Centre, Kingston General Health Research Institute, Kingston, ON, Canada

⁵ Division of Plastic Surgery, Department of Surgery, Queen's University, Kingston, ON, Canada