Published on in Vol 13 (2024)

Preprints (earlier versions) of this paper are available at https://preprints.jmir.org/preprint/54081, first published .
High-Flow Humidified Oxygen as an Early Intervention in Children With Acute Severe Asthma: Protocol for a Feasibility Randomized Controlled Trial

High-Flow Humidified Oxygen as an Early Intervention in Children With Acute Severe Asthma: Protocol for a Feasibility Randomized Controlled Trial

High-Flow Humidified Oxygen as an Early Intervention in Children With Acute Severe Asthma: Protocol for a Feasibility Randomized Controlled Trial

Hector Rojas-Anaya   1, 2 , BEng, PhD ;   Akshat Kapur   3 , MBBS ;   Graham Roberts   4, 5 , DM ;   Damian Roland   6, 7 , BMedSci, BMBS, PhD ;   Atul Gupta   8 , MD ;   Michaela Lazner   9 , MBChB, MMedSci ;   Jane Bayreuther   10 , BMBS ;   John Pappachan   5 , BChir, MA, MB ;   Christina Jones   11 , PhD, CPsychol ;   Stephen Bremner   2 , BSc, MSc, PhD ;   Fleur Cantle   12 , BSc, MBBS, MSc, DCH ;   Paul Seddon   3 , MB, ChB, PGCertMedEd

1 University Hospitals Sussex National Health Service Foundation Trust, Brighton, United Kingdom

2 Brighton and Sussex Clinical Trials Unit, Brighton and Sussex Medical School, Brighton, United Kingdom

3 Respiratory Care, Royal Alexandra Children's Hospital, University Hospitals Sussex National Health Service Foundation Trust, Brighton, United Kingdom

4 Department of Paediatric Allergy and Respiratory Medicine, University of Southampton, Southampton, United Kingdom

5 National Institute for Heath Research Southampton Biomedical Research Centre, University Hospital Southampton National Health Service Foundation Trust, Southampton, United Kingdom

6 Paediatric Emergency Medicine Leicester Academic Group, Children’s Emergency Department, Leicester Royal Infirmary, Leicester, United Kingdom

7 Social science APPlied Healthcare and Improvement REsearch Group, Department of Population Health Sciences, Leicester University, Leicester, United Kingdom

8 Paediatric Respiratory Medicine, King's College Hospital, London, United Kingdom

9 Children's Emergency Department, Royal Alexandra Children's Hospital, University Hospitals Sussex National Health Service Foundation Trust, Brighton, United Kingdom

10 Children's Emergency Department, University Hospital Southampton National Health Service Foundation Trust, Southampton, United Kingdom

11 School of Psychology, Faculty of Health and Medical Sciences, University of Surrey, Guildford, United Kingdom

12 Emergency Department, King's College Hospital, London, United Kingdom

Corresponding Author:

  • Paul Seddon, MB, ChB, PGCertMedEd
  • Respiratory Care
  • Royal Alexandra Children's Hospital
  • University Hospitals Sussex National Health Service Foundation Trust
  • Eastern Road
  • Brighton, BN2 5BE
  • United Kingdom
  • Phone: 44 7714777361
  • Email: seddop@gmail.com