Effect of Semaglutide on Physical Function, Body Composition, and Biomarkers of Aging in Older Adults With Overweight and Insulin Resistance: Protocol for an Open-Labeled Randomized Controlled Trial

Tiffany M Cortes   ^{1, 2, 3} , MD ;   Libia Vasquez   ⁴ , MD ;   Monica C Serra   ^{2, 3, 5} , PhD ;   Ronna Robbins   ⁶ , PhD ;   Allison Stepanenko   ² , MSN ;   Kevin Brown   ² , BS ;   Hannah Barrus   ² , BS ;   Annalisa Campos   ² , BS ;   Sara E Espinoza   ^{5, 7, 8} , MSc, MD ;   Nicolas Musi   ^{7, 8} , MD

¹ Division of Endocrinology, Department of Medicine, University of Texas Health Science Center San Antonio, San Antonio, TX, United States

² Sam & Ann Barshop Institute for Longevity & Aging Studies, University of Texas Health Science Center San Antonio, San Antonio, TX, United States

³ San Antonio Geriatric Research, Education, and Clinical Center, South Texas Veterans Health Care System, San Antonio, TX, United States

⁴ Texas Diabetes Institute, University Health System, San Antonio, TX, United States

⁵ Division of Geriatrics, Gerontology & Palliative Medicine, Department of Medicine, University of Texas Health Science San Antonio, San Antonio, TX, United States

⁶ Department of Nutrition and Food Science, Texas Woman’s University, Denton, TX, United States

⁷ Center for Translational Geroscience, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, United States

⁸ Diabetes and Aging Center, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, United States