Published on in Vol 14 (2025)

Preprints (earlier versions) of this paper are available at https://preprints.jmir.org/preprint/44027, first published .
Novel Versus Conventional Sequencing of β-Blockers, Sodium/Glucose Cotransportor 2 Inhibitors, Angiotensin Receptor-Neprilysin Inhibitors, and Mineralocorticoid Receptor Antagonists in Stable Patients With Heart Failure With Reduced Ejection Fraction (NovCon Sequencing Study): Protocol for a Randomized Controlled Trial

Novel Versus Conventional Sequencing of β-Blockers, Sodium/Glucose Cotransportor 2 Inhibitors, Angiotensin Receptor-Neprilysin Inhibitors, and Mineralocorticoid Receptor Antagonists in Stable Patients With Heart Failure With Reduced Ejection Fraction (NovCon Sequencing Study): Protocol for a Randomized Controlled Trial

Novel Versus Conventional Sequencing of β-Blockers, Sodium/Glucose Cotransportor 2 Inhibitors, Angiotensin Receptor-Neprilysin Inhibitors, and Mineralocorticoid Receptor Antagonists in Stable Patients With Heart Failure With Reduced Ejection Fraction (NovCon Sequencing Study): Protocol for a Randomized Controlled Trial

Sumanth Karamchand   1 , BPharm, MBChB, MMedSc ;   Tsungai Chipamaunga   1 , MBChB, MMed ;   Poobalan Naidoo   2, 3 , BPharm, MBChB, MMedSc ;   Kiolan Naidoo   4 , BPharm, MPharm ;   Virendra Rambiritch   5 , PhD ;   Kevin Ho   6 , MBBCh, MMed ;   Robert Chilton   7 , DO ;   Kyle McMahon   8 , BSc ;   Rory Leisegang   9 , BSc, MBChB, PhD ;   Hellmuth Weich   10, 11, 12 , MBBCh, MMed ;   Karim Hassan   13 , MBChB, MMed

1 Department of Cardiology, Faculty of Medicine and Health Sciences, Stellenbosch University, Stellenbosch, South Africa

2 Department of Internal Medicine, Nelson R Mandela School of Medicine, King Edward VIII Hospital, University of Kwa-Zulu Natal, Durban, South Africa

3 Department of Medicine, Nelson R Mandela School of Medicine, King Edward VIII Hospital, University of Kwa-Zulu Natal, Durban, South Africa

4 School of Law, University of South Africa, Pretoria, South Africa

5 Division of Pharmacology, Department of Pharmaceutical Sciences, University of Kwa-Zulu Natal, Durban, South Africa

6 Department of Cardiology, Life Flora Hospital, Roodeport, South Africa

7 Division of Cardiology, Department of Medicine, University of Texas Health Science Center, San Antonio, TX, United States

8 ABX-CRO advanced pharmaceutical services, Dresden, Germany

9 Department of Pharmacy, University of Uppsala, Uppsala, Sweden

10 Division of Cardiology, Faculty of Medicine and Health Sciences, Tygerberg Hospital, Stellenbosch, South Africa

11 Department of Cardiology, Stellenbosch University, Stellenbosch, South Africa

12 Department of Medicine, Stellenbosch University, Stellenbosch, South Africa

13 Department of Cardiology, Life Bay View Private Hospital, Mossel Bay, South Africa

Corresponding Author: