Clozapine for Treatment-Resistant Disruptive Behaviors in Youths With Autism Spectrum Disorder Aged 10-17 Years: Protocol for an Open-Label Trial

André Luiz Schuh Teixeira da Rosa   ^{1, 2} , MD, MSc ;   Marina Ribeiro Barreto da Costa   ^{1, 2} , MD ;   Gabriela Bezerra Sorato   ^{2, 3} , UG ;   Felipe de Moura Manjabosco   ^{2, 3} , UG ;   Érica Bonganhi de Bem   ^{1, 2} , MD ;   Lucas Dellazari   ² , MD ;   Arthur Bezerra Falcão   ^{1, 2} , MD ;   Lucas de Oliveira Cia   ^{2, 3} , UG ;   Olivia Sorato Bezerra   ⁴ , MD ;   Rogério Boff Borges   ^{5, 6} , MSc ;   Luis Augusto Rohde   ^{7, 8, 9, 10} , MD, MSc, PhD ;   Ana Soledade Graeff-Martins   ^{1, 2} , MD, MSc, PhD

¹ Graduate Program of Psychiatry and Behavioral Sciences, Department of Psychiatry, Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, Brazil

² Division of Child and Adolescent Psychiatry, Department of Psychiatry, Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, Brazil

³ Undergraduate Program of Medicine, Federal University of Health Sciences of Porto Alegre (UFCSPA), Porto Alegre, Brazil

⁴ Child Neurology Unit, Department of Pediatrics, Hospital de Clínicas de Porto Alegre (HCPA), Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, Brazil

⁵ Department of Statistics, Institute of Mathematics and Statistics, Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, Brazil

⁶ Unit of Biostatistics and Data Analysis, Research Directorate, Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre, Brazil

⁷ ADHD Outpatient Program & Developmental Psychiatry Program, Hospital de Clinicas de Porto Alegre (HCPA), Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, Brazil

⁸ Medical Council UNIFAJ, Jaguariúna, Brazil

⁹ Medical Council UNIMAX, Indaiatuba, Brazil

¹⁰ National Institute of Developmental Psychiatry & National Center for Innovation and Research in Mental Health, Brasilia, Brazil